The stimulatory role of LXRα–SREBP-1c in the production of PUFAs enables the possibility for a feedback regulation of hepatic lipogenesis through PUFA mediated repression of SREBP-1c expression. 展开 关键词: PUFAs Fatty acid elongase 5 Liver X receptor Sterol-regulatory binding protein ...
Cholesterol, on the other hand, down-regulates expression of the 12 alpha-hydroxylase gene. In this study, we show that the two sterol regulatory binding proteins (SREBPs) have opposite effects on the 12 alpha-hydroxylase promoter. SREBP-1 activated the 12 alpha-hydroxylase promoter, as it ...
carbon dots; Maillard reaction; antioxidant; biocompatible; PPARγ; C/EBPα; SREBP-1; HMGCR; cytotoxicity Graphical Abstract 1. Introduction Carbon dots (CDs), which were discovered by Xu et al. in 2004, are fluorescent, zero-dimensional nanomaterials with a size below 20 nanometers [1]. ...
The loss of PPARα in adipose tissue causes a significant increase in iNOS, which mediates the switch of macrophage polarity from anti-inflammatory M2 to pro-inflammatory M1. Abbreviations: PPARα, peroxisome proliferator-activated receptor-alpha; SREBP-1, sterol regulatory element-binding protein-1...