Over-expression of these three kinases in 32D cl3 cells resulted in an elevated level of tyrosine phosphorylation and kinase activity. Over-expression of c-src in the same cells, however, did not result in the activation of this kinase, suggesting specificity in which src-like kinases are ...
Giusti AF, Xu W, Hinkle B, Terasaki M, Jaffe LA. Evidence that fertilization activates starfish eggs by sequential activation of a Src‐like kinase and phospholipase c gamma. J Biol Chem 2000; 275: ...
SRC/FGR/YES相关FYN癌基因(FYN)重组蛋白 Recombinant FYN Oncogene Related To SRC/FGR/YES (FYN)SLK; SYN; c-Fyn; Src-like kinase [ PROPERTIES ]Source: Prokaryotic expressionHost: E.coliResidues: Gly2~Leu537Tags: N-terminal His TagSubcellular Location: Membrane, Nucleus, Cytoplasm...
1、c-src激酶是一种非受体酪氨酸激酶,src激酶家族(src kinase family,sfks)有11个成员,其中src、fyn、yes和fgr亲缘关系较近,为i类酶;blk、hck、lck和lyn为ii类酶;frk、srm和brk因与前两组酶亲缘关系较远,为iii类酶。src、fyn和yes在所有细胞类型中都有表达,blk、fgr、hck、lck和lyn主要存在于造血细胞中,s...
accumulation and foam cell-like marker expression in VSMCs. These results demonstrated that beyond its familiar role in regulating inflammation response, TLR4 is a critical regulator in oxLDL-induced foam cell formation in ...
另一个v-Src诱导的基因最初称为血清诱导的激酶,随后被发现与polo样激酶有关,并更名为PLK2 (polo-like kinase 2)。 原文链接 https://mcb.asm.org/content/12/9/4164.long Erikson推测PLK激酶可能在细胞周期控制中起重要作用。他的团队在21...
SH2- and SH3-mediated interactions between focal adhesion kinase and Src. J Biol Chem. 1998; 273 :577–583.Thomas, J. W., B. Ellis, R. J. Boerner, W. B. Knight, G. C. White II, and M. D. Schaller. 1998. SH2- and SH3-mediated interactions between focal adhesion kinase and...
αC Helix as a Switch in the Conformational Transition of Src/CDK-like Kinase Domains 来自 Semantic Scholar 喜欢 0 阅读量: 49 作者:H He,† Ruijun Zhao,§ Bradley M. Dickson,† Robert D. Skeel,CB Post 摘要: One mechanism of regulating the catalytic activity of protein kinases is ...
摘㊀要:类固醇受体辅激活因子(ＳｔｅｒｏｉｄｒｅｃｅｐｔｏｒｃｏａｃｔｉｖａｔｏｒꎬＳｒｃ)是一种由Ｓｒｃ原癌基因编码的非受体型酪氨酸激酶ꎬ属于Ｓｒｃ家族蛋白激酶(Ｓｒｃ￣ｆａｍｉｌｙｋｉｎａｓｅｓꎬＳＦＫｓ)的核心成员.Ｓｒｃ广泛存在于人体细胞中ꎬ可调节细胞分裂㊁运动㊁黏附㊁血管生成和存活...
Yudowski, G. A., Efendiev, R., Pedemonte, C. H., Katz, A. l., Berggren, P. O., and Bertorello, A. M. (2000). Phosphoinositide-3 kinase binds to a proline-rich motif in the Na+, K+誦ATPase alpha subunit and regulates its trafficking. Proc. Natl. Acad. Sci. USA 97,6556...