1.AimTo investigate the effects of inhibition of Src family kinases (SFKs) activation on connexin43 of gap junction in formation of cataract in vitro.研究背景前期研究发现在体外培养的鸡胚晶状体皮质性白内障模型中,抑制Src-家族酪氨酸激酶(SFK)活性能有效阻止皮质性白内障的发生,这提示Src-家族酪氨酸激酶的...
2009. Src family kinases as mediators of endothelial permeability: effects on inflammation and me- tastasis. Cell Tissue Res. 335:249-259.Kim MP, Park SI, Kopetz S, Gallick GE 2009 Src family kinases as mediators of endothelial permeability: effects on inflammation and metastasis. Cell Tissue ...
4. Boggon T J , Eck M J . Structure and regulation of Srcfamily kinases[J]. Oncogene.5.Roskoski, Robert.Src protein-tyrosine kinase structure, mechanism, and small moleculeinhibitors[J]. Pharmacological Research, 2015, 94:9-25.6.Aleshin, A, Finn, etal. SRC: a century of science br...
1) Src family kinases (SFKs) Src-家族酪氨酸激酶 1. AimTo investigate the effects of inhibition of Src family kinases (SFKs) activation on connexin43 of gap junction in formation of cataract in vitro. 研究背景前期研究发现在体外培养的鸡胚晶状体皮质性白内障模型中,抑制Src-家族酪氨酸激酶(SFK)活性...
Src family kinases, key regulators of signal transduction. Oncogene. 2004;23(48):7906-7909. 2.Roskoski R. Src protein-tyrosine kinase structure, mechanism, and small molecule inhibitors. Pharmacol Res. 2015;94:9-25. 3.Frame MC. Src in cancer: deregulation and consequences for cell behaviour...
A group of protein kinases anchored to the cell membrane by a lipid moiety attached to their amino terminal region. Src family kinases are responsible for phosphorylating other proteins. They are...Springer Berlin HeidelbergEncyclopedic Reference of Immunotoxicology...
Structure and regulation of Srcfamily kinases[J]. Oncogene. 5.Roskoski, Robert.Src protein-tyrosine kinase structure, mechanism, and small moleculeinhibitors[J]. Pharmacological Research, 2015, 94:9-25. 6.Aleshin, A, Finn, etal. SRC: a century of science brought to the clinic.[J]. ...
SFK, Src-family kinase; TK, tyrosine kinase. The modular structure of Src-kinases comprises a short N-terminal segment where a myristoylation (or more rarely palmitoylation) site occurs, which is sequentially followed by the so-called Unique domain, an SH3 domain, an SH2 domain, and the TK...
Ang II also activates Src family kinases (SFK) in the vascular system, which has been implicated in cell proliferation and migration. However, the role of SFK in Ang II-induced hypertension is largely unknown. In this study, we found that administration of a SFK inhibitor SU6656 markedly ...
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