网络急性移植物抗宿主病 网络释义 1. 急性移植物抗宿主病 皮质激素耐药的急性移植物抗宿主病(SR-GVHD)是allo-HSCT常见并发症,易导致死亡,常规治疗效果不佳。美国国立卫生 … www.cn-blood.com|基于4个网页
芦可替尼可以抑制GVHD患者中失调的JAK1和JAK2信号传递,进而抑制促炎细胞因子产生和T细胞扩增,促进调节性T细胞发育,最终降低GVHD的发生率和严重程度。慢性GVHD主要是一种慢性炎症反应,芦可替尼具有很好的抑制炎症反应的作用,因此对于慢性GVHD也...
芦可替尼作为一种治疗aGVHD/cGVHD的有效药物,在早期临床试验中主要应用于糖皮质激素耐药或不耐受的患者进行了一些大规模临床试验(REACH1、REACH2),两项临床的积极结果为GVHD患者带来了新的希望。服用芦可替尼后,GVHD症状在得到有效控制的同时,可以逐渐减停糖皮质激素,显著改善糖皮质激素副作用。欧洲ESMO已将芦可替尼...
这一批准基于3期MSB-GVHD001试验的数据,该试验显示第28天的总体缓解率达到70%,完全缓解率为30%。 Remestemcel-L是一种间充质干细胞疗法,通过静脉输注给药,具有免疫调节作用,能够下调促炎细胞因子的产生、增加抗炎细胞因子的产生,并招募自然产生的抗炎细胞到相关组织中,对抗与多种疾病相关的炎症过程。 在治疗SR-aG...
Overall grading of acute GvHD , at the time the patient was considered steroid refractory, was comparable in the 2 groups : grade III-IV was 77% vs 74% in Controls and Begelomab respectively (p=0.7); stage 3-4 skin was 50% vs 57% (p=0.5), stage 3-4 liver was 5% vs 21% in ...
MacMillan ML et al. Pediatric acute GVHD: clinical phenotype and response to upfront steroids.Bone Marrow Transplant2020; 55(1): 165-171 Zeiser R et al. Ruxolitinib for Glucocorticoid-Refractory Acute Graft-versus-Host Disease.N Engl J Med2020;382:1800-10. ...
Eligible patients had Minnesota standard risk (MN-SR) acute GVHD. Patients with centrally assessed Ann Arbor (AA) 1 or 2 biomarker status were included in the primary analysis. Sirolimus was given as a loading dose, followed by maintenance to continue therapeutic levels through at least 56 days...
目的研究突变型单纯疱疹病毒胸苷激酶-更昔洛韦/阿昔洛韦(HSV-sr39TK-GCV/ ACV)系统对小鼠异基因骨髓移植后移植物抗宿主病(GVHD)的影响。方法采用改良的磷酸钙沉淀法,以携带HSV-sr39TK基因的慢病毒感染C57BL/6小鼠的脾淋巴细胞,制得sr39TK+T淋巴细胞。以C57BL/6小鼠为供者,Balb/c小鼠为受者进行骨...
lesions (OLCL) induced by allergic contact stomatitis, which is commonly caused by metallic restora- tions; (2) oral lichenoid drug reactions (OLDR) induced by certain medications; and (3) oral lichenoid lesions in graft-versus-host disease induced by marrow grafts (OLL-GVHD)6,7. OLDR and...
Treatment options for steroid-refractory GVHD (SR-GVHD) are unsatisfactory and prognosis is poor. Inflammatory cytokines IL-2 and TNF-α are important medi... A Rager,N Frey,SC Goldstein,... - 《Bone Marrow Transplantation》 被引量: 44发表: 2011年 Highly aligned, spin polarized thin films ...