Membrane potential determines calcium alternans through modulation of SR Ca2+ load and L-type Ca2+ current. J Mol Cell Cardiol 2017;105:49-58.Kanaporis G, Blatter LA. Membrane potential deter- mines calcium alternans through modulation of SR Ca2C load and L-type Ca2C current. J Mol Cell ...
In heart, spontaneous local increases in cytosolic Ca2+ concentration ([Ca2+]i) called "Ca2+ sparks" may be fundamental events underlying both excitation-contraction coupling and resting Ca2+ leak from the sarcoplasmic reticulum (SR). In this study, resting Ca2+ sparks were analyzed in rabbit an...
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Furthermore, cytosolic Ca2+ levels were elevated during diastole (229±20 versus 164±8 nmol/L, P<0.05). Most likely, this resulted from an increased SR Ca2+ leak in AF (P<0.05), which was not attributable to higher SR Ca2+ load. Tetracaine experiments confirmed that SR Ca2+ leak ...
The importance of sarcoplasmic reticulum (SR) Ca2+-handling in heart has led to detailed understanding of Ca2+-release and re-uptake protein complexes, whi
Na+- dependent SR Ca2+ overload induces arrhythmogenic events in mouse cardiomyocytes with a human CPVT mutation. Cardiovasc Res. 2010;87(1):50-9... S Simon,FR Heinzel,W Stefanie,... - 《Cardiovascular Research》 被引量: 134发表: 2010年 Alterations in Ca[sup 2+] cycling by lysoplasm...
Vickers hardness of the tape samples was measured on the polished cross sections with 0.05 kg load and 10 s duration in a row at the center of the superconducting cross section. The phase composition and microstructure was characterized by X-ray diffraction (XRD), energy dispersive X-ray ...
35, 52,35, 52 It is reported that activating the expression of cardiac CaSR would stimulate the Ca2+/calmodulin-dependent protein kinase II (CaMKII) pathway, which would lead to cardiomyocyte hypertrophy and death in a variety of cardiovascular diseases.53 Previous studies have shown that the ...
Normal heart contraction and rhythm relies on the proper flow of calcium ions (Ca2+) into cardiac cells and between their intracellular organelles, and any disruption can lead to arrhythmia and sudden cardiac death. Electrical excitation of the surface membrane activates voltage-dependent L-type Ca2...