图1. 新冠病毒通过HDL-SR-B1入侵细胞的机制 高密度脂蛋白（High-density lipoprotein，HDL）是脂蛋白的一种，是由蛋白质和脂质组成的大分子复合物。借由SR-B1受体，HDL能够参与胆固醇的逆向转运，将胆固醇从细胞外组织转运到细胞内研究者首先对新冠病毒S蛋白的一级序列进行了分析，发现了六个可能的胆固醇结合基序。进...
高密度脂蛋白(HDL)与其主要受体B类1型清道夫受体(SR-B1)的结合对于降低血浆胆固醇水平和降低心血管疾病风险至关重要。这篇综述对SR-B1的结构元件如何驱动有效功能提供了新的见解,重点是双向胆固醇转运。 Recent Findings We have generated...
SR-B1 also mediates cholesterol efflux from cells into HDL. When assayed, only V32M- and G319V-SR-B1 decreased cholesterol efflux to HDL by 25 and 52%, respectively, compared to wild-type. Additionally, we demonstrated a decrease in total and cell surface expression of the G319V-SR-B1 ...
B类Ⅰ型清道夫受体(scavenger receptor class B type Ⅰ,SR-BⅠ)是一种高亲和力的高密度脂蛋白(high density lipoprotein,HDL)受体。研究发现,SR-BⅠ在多种恶性肿瘤中过表达,并且参与肿瘤的增殖、迁移、血管生成和信号调节。SR-BⅠ有望成为恶性肿瘤诊断、预后甚至治疗靶点的潜在标记物。文章就目前SR-BⅠ蛋白与...
近年多项研究表明,脂多糖(1ip叩0lysaccharides,LPS)、血清淀粉样蛋白A(serumamyloidAprotein,SAA)等致炎因子能调节SR—B1的表达,影响其功能;SR—B1也能调节C反应蛋白(C.reactiveprotein,CRP)、肿瘤坏死因子Or.(tumornecrosisfaetort~;TNFe~)等炎症因子表达,而且,它也参与HDL的抗炎反应过程,因此,SR—B1在AS性...
r–t, Plasma total cholesterol, triglyceride, and HDL cholesterol. u, Representative lipoprotein profiles. v, Immunoblotting of SR-B1 abundance in liver, showing findings for two samples per group. Data are mean ± s.e.m; P values calculated by two-sided Student’s t-test. Source data ...
Notably, SR-B1 also has an important function in increasing vitamin E uptake from HDL into type II pneumocytes found within the lung [36]. This is significant, as a recent meta-analysis published by Cheng et al. found evidence that increased vitamin E intake was associated with a lower ...
[3]LEIVA A,VERDEJO H,BENITEZ A L,et al.Mechanisms regulating hepatic SR-B1 expression and their impact on HDL metabolism[J].Atherosclerosis,2011,217(2):299-307. [4]常冠楠,徐新,张社兵.B类I型清道夫受体的研究进展[J].中西医结合心脑血管病杂志,2010,8(9):1126-1129. [5]YANG X P,SETHI ...
Although the DiI-HDL uptake is significantly higher in infected WT hepatocytes compared to the SR-BI-/- counterparts (P < 0.01), Ad-ATPase-B1 infection increased DiI-HDL uptake similarly in both groups (Table 1), suggesting that the lack of SR-BI does not affect ATPase-B1 function. ATP ...