Stage 0 squamous cell carcinoma:This is the earliest stage of SCC. Cancer cells are only in the top layer of your skin. Stage I squamous cell carcinoma:The cancer is in the top and middle layers of your skin. Stage II squamous cell carcinoma:Cancer cells are in multiple layers of your ...
squamous cell carcinoma self-renewal differentiation transcriptional network PITX1 SOX2 Klf4 TRP63 cancer stem cell Introduction Balanced stem cell renewal and differentiation maintains tissue homeostasis, while their de-regulation enables tumor formation (Meacham and Morrison, 2013). Skin epithelium emerged ...
The cell identity of malignant cells and how they acquire it are fundamental for our understanding of cancer. Here, we report that esophageal squamous cell carcinoma (ESCC) cells display molecular features equally similar but distinct to all three types of normal esophageal epithelial cells, which ...
and lay a heavy burden on the public health system. Non-small cell lung cancer (NSCLC) takes up approximately 85% of lung cancer, and 25–30% of NSCLC patients can be classified into lung squamous cell carcinoma (LUSC) [2]. Unlike other NSCLCs, LUSC ...
cell pool, initiating differentiation prematurely and leading to thinning of the IFE as well as impaired wound healing12. Thus, the role of MYC in the epidermis is complex, and tight regulation of MYC function is likely important for normal skin homeostasis. Several mouse models have been ...
Tumor metabolism is a crucial factor for the carcinogenesis of oral squamous cell carcinoma (OSCC). Expression of IGF-R1, glycolysis-related proteins (GLUT-1, HK 2, PFK-1, LDHA, TKTL1), mitochondrial enzymes (SDHA, SDHB, ATP synthase) were analyzed in no
Cutaneous squamous cell carcinoma (cSCC) is the second most prevalent form of skin cancer, showing a rapid increasing incidence worldwide. Although most cSCC can be cured by surgery, a sizeable number of cases are diagnosed at advanced stages, with local invasion and distant metastatic lesions. ...
a gradual decrease in the TACSTD2-positive cell population in the upper layers of squamous epithelia was found during the early stages of cervical SCC progression, from CON, CIN1 to CIN2/3. In SCCs, TACSTD2 staining was heterogenous and was detected in some well-differentiated epithelial cel...
Cutaneous squamous cell carcinoma (SCC) is the second most frequent skin cancer, accounting for approximately 20% of all cutaneous malignancies, and with an increasing incidence due to the progressive increment of the average age of life. The diagnosis is usually firstly suspected based on clinical...
apoptosis;cannabis;cannabinoids;cancer;HNSCC carcinoma;oral cancer;CBC;CBD 1. Introduction Head and neck squamous cell carcinoma (HNSCC) [1] is the most common malignancy in the head and neck region. It develops from the mucosal epithelium in the oral cavity pharynx and larynx. HNSCC is the si...