Stage I squamous cell carcinoma:The cancer is in the top and middle layers of your skin. Stage II squamous cell carcinoma:Cancer cells are in multiple layers of your skin and around your nerves. Stage III squamous cell carcinoma:Cancer has been found in your skin and has spread to your ly...
Summary A clinically detectable, frankly invasive, squamous cell carcinoma of the uterine cervix evolves through a series of step-like stages, at any one of which, except the last, its progress can be arrested. These stages are intraepithelial neoplasia, early stromal invasion, micro-carcinoma and...
Basal tumor propagating cells (TPCs) control squamous cell carcinoma (SCC) growth by self-renewing and differentiating into supra-basal SCC cells, which lack proliferative potential. While transcription factors such as SOX2 and KLF4 can drive these behaviors, their molecular roles and regulatory interac...
Esophageal cancer is the sixth most common cause of mortality worldwide, accounting for almost 508,000 deaths annually1,2. Esophageal squamous cell carcinoma (ESCC) is the most common histological type of esophageal cancer throughout Asia, specifically Japan3,4. ESCC diagnosed in advanced stages of...
squamous cell carcinoma; KICH, Kidney Chromophobe; KIRC, Kidney renal clear cell carcinoma; KIRP, Kidney renal papillary cell carcinoma; LAML, Acute Myeloid Leukemia; LGG, Brain Lower Grade Glioma; LIHC, Liver hepatocellular carcinoma; LUAD, Lung adenocarcinoma; LUSC, Lung squamous cell carcinoma;...
Oral squamous cell carcinoma (OSCC) is the most common malignancy of the oromaxillofacial region, accounting for more than 90% of oral cancers [1]. Although therapeutic strategies have greatly improved in recent years, the 5-year survival rate of OSCC remains at approximately 60% [2,3,4], ...
Squamous Cell Carcinoma of the Oral Cavity, Oropharynx, and Larynx: A Scoping Review of Treatment Guidelines Worldwide. Cancers 2023, 15, 4405. https://doi.org/10.3390/cancers15174405 AMA Style Arboleda LPA, de Carvalho GB, Santos-Silva AR, Fernandes GA, Vartanian JG, Conway DI, Virani S...
Sinonasal squamous cell carcinoma (SNSCC) arises as either de novo SCC (DN-SCC) or as inverted papilloma–associated SCC (IP-SCC) [5]. IP-SCC is not simply a mixture of two separate tumors, but a malignant transformation of benign inverted papilloma (IP) [6]. The pathogenesis and ...
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Precancerous lesions of the oral mucosa, especially those accompanied by moderate to severe dysplasia, contribute to the initiation of oral squamous cell carcinoma (OSCC). However, the cellular compositions and spatial organization of the precancerous st