[5]Rosenbaum JN, Bloom R, Forys JT,et al. Genomic heterogeneity of ALK fusion breakpoints in non-small-cell lung cancer. Mod Pathol. 2018 May;31(5):791-808. [6]Gu FF, Zhang Y, Liu YY, Hong XH,et al. ...
Reduced expression of SPTBN1 has been found to correlate with shorter survival of patients with hepatocellular cancer, pancreatic cancer and other malignancies of the gastrointestinal tract, suggesting tumor suppression ability of this protein. Properties Storage Instructions All the reagents are stored at ...
Gene knockdown in either SPTAN1 or SPTBN1, mimicking silencing mutations in cancer tissues, caused cell morphology changes, DNA breaks, and alternations in cytokine profiles via activating cGAS-STING mediated interferon signaling. Xenograft tumor models also indicate accelerated tumor growth in SPTAN1-...
Reduced expression of SPTBN1 has been found to correlate with shorter survival of patients with hepatocellular cancer, pancreatic cancer and other malignancies of the gastrointestinal tract, suggesting tumor suppression ability of this protein. 实验方案 Product Specific Protocols WB protocol for SPTBN1 ...
Clin Cancer Res, 11 (2005), pp. 5281-5291 View in ScopusGoogle Scholar 13 F. van Rhee, D. Savage, J. Blackwell, et al. Adoptive immunotherapy for relapse of chronic myeloid leukemia after allogeneic bone marrow transplant: equal efficacy of lymphocytes from sibling and matched unrelated donor...
[4]Du X, Zhang J, Gao H, Tai Y. A novel break site of EML4-ALK report and a rare PRKAR1A-ALK report analyzed by different ALK detection platforms in non-small cell lung cancer patients. Thorac Cancer. 2021 Oct;12(20):2773-2779. ...
LSKO mice subjected to DEN with or without WD had less severe cancer than did wild-type mice. Compared to the HCC in the control mice, the number of liver tumors in the LSKO mice was lower, the size of the tumors was smaller, and the tumors were less proliferative based on KI67 ...
Therefore, c-Met overexpression,HER-2gene amplification, andSPTBN1-ALK gene fusion can coexist in lung adenocarcinoma and may become a potential biomarker of cancer refractory to crizotinib, chemotherapy, and radiotherapy as well as of a relatively poor prognosis. In addition, the novelSPTBN1-ALK ...
SPTBN1Renal clear cell carcinomaPrognosisGlycolysisGPT2BiomarkerMetabolic reprogrammingRenal clear cell carcinoma (ccRCC) is the most prevalent tumors worldwide. Discovering effective biomarkers is essential to monitor the prognosis and provide alternative clinical options. SPTBN1 is implicated in various cancer...
This disclosure provides methods of treating obesity, nonalcohol-related fatty liver disease, nonalcoholic steatohepatitis, or hepatocellular cancer in a subject in need thereof, the method comprising administering a therapeutically effective amount of at least one siRNA molecule targeting SPTBN1.MISHRA, ...