Importantly, upregulating SPP1 promoted, while silencing SPP1 attenuated epithelial-mesenchymal-transition (EMT). Our results further demonstrated that SPP1 overexpression maintains the activation of PI3K/AKT and ERK1/2 signaling pathways. Overall, our findings unraveled the functional role and clinical ...
Zhao K-W, Brochmann Murray EJ, Murray SS. 2015. Spp24 derivatives stimulate a Gi-protein coupled receptor-Erk1/2 signaling pathway and modulate gene expressions in W-20-17 cells. J Cell Biochem 116:767-777.Zhao KW, Murray EJ and Murray SS: Spp24 derivatives stimulate a Gi‑...