Conclusions LLGL1 possessed tumor suppressor role as an inhibitor of chemoresistance by regulating OSMR-ERK2/sp1 signalings.doi:10.1016/j.jcmgh.2020.06.009Yin-Xin ZhuChi Han LiGuolin LiHuiyi FengYangchao ChenCellular and Molecular Gastroenterology and Hepatology...
[1]低功率激光照射通过激活ERK/Sp1信号通路促进血管再生 本文档由【中文word文档库(http:\/\/.wordwendang)】.wordwendang(http:\/\/.wordwendang)提供,转载分发敬请保留本信息;中文word文档库(http:\/\/.wordwendang)免费提供...
本研究首次揭示了 Sch B 通过抑制 CXCL2/ERK/DUSP11 轴发挥抗 CRC 作用的新机制,这不仅加深了人们对传统中药抗癌作用的理解,也为临床应用 Sch B 治疗 CRC 提供了有力的理论支持。不过,研究也存在一些局限性,比如 Sch B 调节 CXCL2/ERK/DUSP11 轴的直接靶点尚不明确,其对 DUSP11 的调控机制也有待进一步...
?背景与目的:了解erk1/2_sp1信号通路对肺癌细胞血管内皮生长因子(vegf)基因的调控作用。材料与方法:采用激酶特异抑制剂pd98059抑制erk1/2的活性,westernblot检测erk1/2的表达。rna干扰技术沉默sp1基因,mercury信号通路系统检测sp1的转录活性。rt_pcr检测vegf和sp1基因的变化。结果:erk1/2激酶的活性几乎可被150μmol...
In the CSE-stimulated NCI-H292 cells, PYC significantly inhibited the phosphorylation of Erk, sp1 expression, MUC5AC and levels of pro-inflammatory mediators in a concentration-dependent manner at the mRNA level. In the COPD model, PYC decreased the inflammatory cell count in the BALF, as ...
背景与目的:了解ERK1/2-Sp1信号通路对肺癌细胞血管内皮生长因子(VEGF)基因的调控作用。材料与方法:采用激酶特异抑制剂PD98059抑制ERK1/2的活性,Western blot检测ERK1/2的表达。RNA干扰技术沉默Sp1基因,Mercury信号通路系统检测Sp1的转录活性。RT-PCR检测VEGF和Sp1基因的变化。结果:ERK1/2激酶的活性几乎可被150μmol...
背景与目的:了解ERK1/2-Sp1信号通路对肺癌细胞血管内皮生长因子(VEGF)基因的调控作用。材料与方法:采用激酶特异抑制剂PD98059抑制ERK1/2的活性,Western blot检测ERK1/2的表达。RNA干扰技术沉默Sp1基因,Mercury信号通路系统检测Sp1的转录活性。RT-PCR检测VEGF和Sp1基因的变化。结果:ERK1/2激酶的活性几乎可被150μmol...
摘要: 背景与目的:了解ERK1/2-Sp1信号通路对肺癌细胞血管内皮生长因子(VEGF)基因的调控作用.材料与方法:采用激酶特异抑制剂PD98059抑制ERK1/2的活性,Western blot检测ERK1/2的表达.RNA干扰技术沉默Sp1基因,Mercury信号通路系统检测Sp1的转录活性.RT-PCR检测VEGF和S... 查看全部>> ...
IPF-fibroblast proliferation was inhibited by treprostinil through increased expression of the Erk1/2 inhibitor DUSP1. These data suggest that proliferation control via miR17-92 and C/EBP-β is disrupted in IPF-fibroblasts. Therefore, the inhibition of early stages of signaling cascades or specific...
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