Macrophage polarizationPD-L1SPP1TAMsTumor-associated macrophages (TAMs) polarization represents a key regulatory process of tumor progression. However, the underlying mechanisms are unclear. This study aimed to investigate the relationship between secreted phosphoprotein 1 (SPP1) and TAMs in lung ...
Macrophage polarization was identified by flow cytometric analysis. Cell migration and apoptosis were assessed by Transwell migration assays and flow cytometric analysis, respectively. SPP1 is highly expressed in tumor tissues and TAMs isolated from patients with an advanced TNM stage, and also in PMA...
Macrophage infiltration plays a central role in AS and was previously thought to be a late consequence of steatosis. However, recent studies have shown that the activation and infiltration of macrophages are also early initiating event in NASH. Inhibition of macrophage infiltration has been shown to ...
There is growing evidence that the outcome of RVF is closely related to the immune response. This study is to explore SPP1 as a potential diagnostic marker related to the infiltration of immune cells in RVF. Methods: The gene expression profile of GSE161473 was downloaded from Gene Expression ...
(Fig.4aand Supplementary Fig.2c), which was shown to activate M1-like TAMs and promote the malignant migration of cancer58. In addition,VCAN+macrophages (n = 600) were identified by high expression ofVCAN, and another macrophage subtype,C1QC+MRC1−macrophages (n = 1480), were ...
Moreover, we find that platelets, the most abundant source of CXCL4 in vivo, drive profibrotic Spp1 macrophage differentiation. Single nuclear RNA sequencing with ligand-receptor interaction analysis reveals that macrophages orchestrate fibroblast activation via Spp1, Fn1, and Sema3 crosstalk. ...
EWSR1-induced circNEIL3 promotes glioma progression and exosome-mediated macrophage immunosuppressive polarization via stabilizing IGF2BP3. Mol Cancer. 2022;21(1):16. https://doi.org/10.1186/s12943-021-01485-6. Article CAS PubMed PubMed Central Google Scholar Zhao S, Mi Y, Zheng B, et ...
(Fig.4aand Supplementary Fig.2c), which was shown to activate M1-like TAMs and promote the malignant migration of cancer58. In addition,VCAN+macrophages (n = 600) were identified by high expression ofVCAN, and another macrophage subtype,C1QC+MRC1−macrophages (n = 1480), were ...