与此同时,作者还通过组织学检测分析验证了单细胞测序结果的准确性和可靠性,并且展示了肿瘤微环境内部基于空间的转录组数据。具体来说,作者发现CXCL9和SPP1(简称CS)表达所定义的巨噬细胞极性,而不是传统的M1和M2分子标签,与预后情况具有明显的相关性。CS...
与此同时,作者还通过组织学检测分析验证了单细胞测序结果的准确性和可靠性,并且展示了肿瘤微环境内部基于空间的转录组数据。具体来说,作者发现CXCL9和SPP1(简称CS)表达所定义的巨噬细胞极性,而不是传统的M1和M2分子标签,与预后情况具有明显的相关性。CS巨噬细胞极性同样可以表征促肿瘤或者是抑肿瘤的有序网络,包括肿...
CXCL9与CXCR3结合。CXCL9在SPP1+巨噬细胞中也高表达,CXCR3是CD8+ T细胞和Treg细胞表达的受体,SPP1+巨噬细胞也可通过CXCL9-CXCR3招募CD8+ T细胞和Treg到侵袭前沿中。同时,空间转录组上分子表达定位的结果也显示,这些分子(CXCL9、CXCL16)和细胞(SPP1+巨噬细胞、CD8+ T细胞和Treg细胞)在侵袭前沿高表达(图6. ...
a NASH model was constructed using free fatty acid-induced human L02 cells, an AS model was constructed using lipopolysaccharide-induced HUVECs, and a co-morbidity model was constructed using L02 cells and HUVECs to verify Hub gene expression. The result showed that a total of 113 genes...
This article consolidates the significance and prospects of CXCL9:SPP1 as a novel indicator for tumor development and prognosis, while also proposing future research directions and addressing potential challenges in this promising field.doi:10.1186/s12943-023-01931-7Su, Xinming...
内容提示: CANCER IMMUNOLOGYCXCL9:SPP1 macrophage polarity identifies a networkof cellular programs that control human cancersRuben Bill 1,2,3,4,5 †, Pratyaksha Wirapati 1,2,3 †, Marius Messemaker 4,6 , Whijae Roh 7 , Beatrice Zitti 1,2,3 ,Florent Duval 1,2,3 , Máté Kiss 1...
CXCL9:SPP1 macrophage polarity identifies a network of cellular programs that control human cancers CXCL9:SPP1巨噬细胞极性识别控制人类癌症的细胞程序网络 相关领域 极性(国际关系)巨噬细胞肿瘤微环境癌症生物癌症研究细胞医学肿瘤细胞内科学遗传学体外
However, recent studies revealed that in almost all cancers, both M1 and M2 gene signatures could be identified in the same macrophage subpopulation. What’s more, a recent study focused on HNSCC suggested that CXCL9-SPP1 might be a better classification system to define the polarity and ...
This study delved into the molecular mechanisms underlying mechanical stress-induced intervertebral disc degeneration (msi-IDD) through single-cell and hig
CXCL9:SPP1 macrophage polarity identifies a network of cellular programs that control human cancers. Science. 2023;(6657):515–24. Article Google Scholar Wang C, Li Y, Wang L, Han Y, Gao X, Li T, Liu M, Dai L, Du R. SPP1 represents a therapeutic target that promotes the ...