splicing factor 45) RBM17 A gene on chromosome 10p15.1 that encodes an RNA-binding protein which is part of the spliceosome complex and functions in RNA splicing. RBM17 binds to the single-stranded 3'AG at the exon/intron interface and promotes its utilisation in the second catalytic step....
We identified a known alternative splicing regulator SPF45 (RBM17) as a general splicing factor that is essential to splice out this 56-nt intron. Whole-transcriptome sequencing of SPF45 deficient cells revealed that SPF45 is specifically required for the efficient splicing of many short introns....
43. In particular, it controls AS of a variety of pre-mRNAs of cancer-associated genes42,58,59,60. For instance, hnRNPM mediates AS of fibroblast growth factor receptor 2 (FGFR2) and CD44 pre-mRNAs to promote EMT58,59,60. Moreover, hnRNPM guides an AS program involving multiple...
YBX1 interactome is enriched for GO term mRNA splicing factor (green) and Ribonucleoproteins (blue) assessed by Fisher’s exact test. Fold enrichment of YBX1 and MAPK1 in JAK2VF cells compared to IgG control plotted against –log10 Student t-test P value. g, Scatter plot of YBX1 ...
In SMN1, recruitment is facilitated by an ESE near the 5′ end of exon 7 that binds splicing factor SF2/ASF, which may also act in conjunction with hnRNP-Q1 (Chen et al., 2008). An additional ESE in the middle of exon 7 enhances inclusion through recruitment of Htra2β1, which ...
determination in E11 gonads: control of mRNA splicing (Son: Son DNA binding protein), control nuclear-cytoplasmic transport (Xpo1: exportin 1), repressor of germ cell-related gene expression (Mga), and testis-specific splicing (Taf1: TATA-box binding protein associated factor 1, on chr X)....
Involvement of splicing factor-1 in β-catenin/T-cell factor-4-mediated gene transactivation and pre-mRNA splicing Gastroenterology, 132 (2007), pp. 1039-1054 View PDFView articleView in ScopusGoogle Scholar 45 P.J. French, J. Peeters, S. Horsman, E. Duijm, I. Siccama, M.J. van de...
The DAS genes identified encode proteins with various functions, e.g. a protein kinase superfamily protein (Pp1s22_429V6), translation initiation factor IF2/IF5 (Pp1s626_4V6), transcription initiation factor TFIID subunit 7 (Pp1s111_159V6), regulatory components of ABA receptor 3 (Pp1s97_...
There are 858 genes with >10% CHH modifications in EHB and 529 genes with >5% CHH modifications in AHB. Analysis with DAVID[32]. b, Distalless is a Hox gene and a transcription factor with high amounts of CHH modifications in the introns of both AHB and EHB. Full size image...
Here we provide the first evidence that a DNA-binding protein, CCCTC-binding factor (CTCF), can promote inclusion of weak upstream exons by mediating local RNA polymerase II pausing both in a mammalian model system for alternative splicing, CD45, and genome-wide. We further show that CTCF ...