Eperon et al., " The role of nucleotide sequences in splice site selection in eukaryotic pre-messenger RNA " Nature 324:280-282 (1986).Eperon LP, Estibeiro JP, Eperon IC (1986) The role of nucleotide sequences in splice site selection in eukaryotic pre-messenger RNA. Nature 324(6094):...
NEWS & VIEWS RESEARCH Upstream intron Downstream intron a sequence sequence 3' Splice 5' Splice site site Precursor RNA First step Second step Mature mRNA b RS exon Competing 5' splice sites First step Second step Second step NMD Figure 1 | Mechanisms of recursive splicing. a, In ...
We report that the 3' splice site associated with the alternatively spliced exon 6 of the Fas receptor CD95 displays strict sequence requirements and that a mutation that disrupts this particular sequence arrangement leads to constitutive exon 6 skipping in a patient suffering from autoimmune lymphopro...
5′ splice site defines a sequence at the 5′ end of an intron, which is the 3′ end of an exon. The human 5′ splice site is described by the consensus CAGgtaagt. Only the gt is invariable, all other positions can deviate from the consensus sequence. Capital letters are located in...
The HS3D dataset is publicly available and well-defined in false and true splice site sequences. The HS3D dataset is selected since it was successfully used in the CNN and BLSTM-based neural network approaches for splice site recognition, as listed in (Table 3) with the performance measures ...
In addition, SpliceFinder performs well on the genomic sequences of Drosophila melanogaster, Mus musculus, Rattus, and Danio rerio without retraining. Conclusion Based on CNN, we have proposed a new ab initio splice site prediction tool, SpliceFinder, which generates less false positives and can ...
While some mutations in splice sites cause altered splicing, many changes to splice site sequences do not change the splicing pattern. In other cases, the splicing machinery may not simply jump over a bad splice site to the next splice site that is normally used in that gene; instead, alter...
网络部位缺失 网络释义 1. 部位缺失 ...、框架转移的缺失 (frame-shift)或接合部位缺失(splice-site)—散发于整个基因之中。 blog.sina.com.cn|基于2个网页 释义: 全部,部位缺失
Interactions between the 3′ splice site sequence and the U5 protein have also been reported (Chiara et al., 1997). Elements within the non-splice sites of the RNA sequence also affect the recognition and use of splice sites by the splicing machinery. These elements include intronic splicing ...
bindingsequenceatthe59-splicesite,whichfrequentlycontainsaGUdinucleotide4ntdownstreamfromthedominantsplice site.Surprisingly,;50%ofduplicated39-YAGsplicejunctionsaresubjecttoalternativesplicing.Thishighprobabilityof alternative39-splice-siteactivationincloseproximityofthedominant39-splicesitesuggeststhatthesecondstepofthespl...