A systematic test showed that, surprisingly, the exon sequences known to modulate exon 11 skipping were not limiting, but the 3’ splice site regions adjacent to exons 11 and 12 were too weak to support splicing when inserted into a globin intron. UV-crosslinking experiments showed binding of...
Wobble splicing regulation at tandem splice sites Moreover, we found that the NAGNAG motif and its upstream region to the branch point sequence play an important role in 3' splice site selection for NAGNAG wobble splicing. Mutations in the region between the branch site and the ... KW Tsai...
Conserved stem–loop structures in the HIV-1 RNA region containing the A3 3′ splice site and its cis-regulatory element: possible involvement in RNA splicing 机译:HIV-1 RNA区域中包含A3 3'剪接位点及其顺式调控元件的保守茎环结构:可能参与RNA剪接 ...
Rhode, B.M., Hartmuth, K., Westhof, E., and Luhrmann R. (2006). Proximity of conserved U6 and U2 snRNA elements to the 5' splice site region in activated spliceosomes. EMBO J. 25, 2475-2486. doi: 10.1038/sj.emboj.76 01134...
Titin population splice site/region allele frequency spectrum.Oyediran, AkinrinadeJuha, W. KoskenvuoTeroPekka, Alastalo
2003. Spatial organization of protein-RNA interactions in the branch site-3¢ splice site region during pre-mRNA splicing in yeast. Mol. Cell. Biol. 23: 4174-4186.McPheeters DS, Muhlenkamp P. Spatial organization of protein-RNA interactions in the branch site-3' splice site region during ...
Provided is a method for modulating RNA splicing by inducing a base mutation at a splice site or a base substitution in a polypyrimidine region. The method comprising: expressing a targeted cytosine deaminase in a cell, to induce AG at a 3' splice site of an intron of interest in a gene...
Computer analysis of the sequence encoding the red fluorescent protein Katushka revealed a strong donor splice site in the 3'-terminal region. A model vector encoding protein Katushka and green fluorescent protein TagGFP2 separated by a fragment of the gene tafazzin, has been constructed for ...
The mutated splice site is located within the first repeat of a minisatellite region. Each repeat in this region contains a normally silent pseudo splice site. By an electrophoretic mobility shift assay (EMSA) the decrease of the binding of the nuclear factor HNF-4 by the promoter mutation -...
As used herein, proteins are deemed to be “substantially similar” if: (a) they are encoded by a nucleotide sequence which is derived from the coding region of a gene which encodes the protein (including, for example, portions of... ME Brunkow,EW Jeffery,KA Hjerrild,... 被引量: 0发...