Change negative splice site of the heterologous gene that is expressed in fungi(57) [Abstract] The present invention relates to a method for obtaining a fungal host cell comprising a nucleic acid sequence encoding a heterologous polypeptide negative splice sites one has been changed at least in ...
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Furthermore, finite element program ABAQUS6.5 was also used to simulate experimental course. Results show that the change of ply splice angle will lead to shear stress concentration on 0 ply in splice region. But the average of shear stress along notch root of specimens almost does not change....
splice_region_variant => 8, # A sequence variant in which a change has occurred within the region of the splice site, either within 1-3 bases of the exon or 3-8 bases of the intron Splice_region: 变异发生在splice site区域内或者外显子的1-3碱基处或者内含子的3-8碱基处 Splice_Site ret...
Splice site variant alleles can also exhibit diminished enzyme activity; by modifying the way in which introns are assembled, the resulting transcript is radically changed, as is the expressed protein. Allelic variation in the regulatory region of a gene can change the transcription level of that ...
An EMS-induced single-base mutation at a splice site caused abnormal RNA splicing and resulted in the gene inactivation and the lack of Wx-A1 protein in a ... M Luo,J Ding,Y Li,... - 《Theoretical & Applied Genetics》 被引量: 0发表: 2019年 A single-base change at a splice accept...
While some mutations in splice sites cause altered splicing, many changes to splice site sequences do not change the splicing pattern. In other cases, the splicing machinery may not simply jump over a bad splice site to the next splice site that is normally used in that gene; instead, alter...
Using several NF1 donor sites and SELEX approaches as experimental models, we have examined the binding properties of particular sequence motifs such as GGGU found in donor sites, and how the sequence context can change their interaction with hnRNPs such as H/F and A1/A2. Our results clearly...
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SpliceTransformer(SpTransformer) is a deep learning tool to predict tissue specific splicing site from pre-mRNA sequence - ShenLab-Genomics/SpliceTransformer