It also functions as a site for blood cell storage and quality control. Surgeons most frequently are called upon to perform urgent splenectomy in the setting of trauma, but numerous indications also exist for elective splenectomy. An understanding of the spleen's anatomy and physiologic function is...
Definition (NCI)A non-neoplastic or neoplastic disorder affecting the spleen. Examples include infection, hemangioma, lymphoma, leukemia and angiosarcoma. Definition (CSP)condition in which there is a deviation from or interruption of the normal structure or function of the spleen. ...
The main immunological function of the spleen is to filter the blood by trapping bloodborne microbes and producing an immune response to them. It is particularly important for B cell responses to polysaccharide antigens. The spleen is formed partly by lymphatic tissue which produces T lymphocytes a...
Anatomy and Physiology The Spleen: Anatomy and Function The spleen is a small, well-perfused organ that receives about 5% of the total cardiac output. In adults, the spleen weighs between 150 and 200 g and measures approximately 11 cm in length. ...
"Better understanding these mechanisms will elucidate how altered function of the vagus nerve in conditions like sepsis and autoimmune disease may impact immune function and could lead to new therapeutic approaches for these conditions." In the study, the Feinstein Institutes' team discovered that acety...
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The liver is the largest organ and carries out the most complex biological functions in the body. It secretes bile, synthesizes proteins, metabolizes nutrients, hormones, and drugs, and detoxifies noxious endogenous and exogenous substrates. To accomplis
The major function of the spleen is the continuous filtration of circulating blood, which is reflected in its histological structure. The internal tissue of the spleen is divided into two distinct macroscopic compartments: the red and white pulp (Mebius and Kraal, 2005: Fig. 1). The red pulp...
thereby limiting bacterial growth. Another substance that provides protection against microbes incidentally to its primary cellular role is thebloodproteintransferrin. The normal function of transferrin is to bind molecules of iron that are absorbed into the bloodstream through the gut and to deliver the...
The spleen is the largest immune organ in the body and plays a vital role in regulating innate and acquired immune function after stroke [121]. Evidence has shown that spleen size is negatively correlated with cerebral infarct volume in stroke, suggesting the importance of spleen response [122]...