That’s probably a good start on resources that will help you gain an understanding of spinal fusion and the type of recovery you can expect. Remember that age, physical condition and other medical conditions all factor into how your case unfolds. No two people are alike. That’s why it’...
The management of CSCIWFD remains a highly debated topic within the spine community due to its highly variable clinical presentation, ranging from mild sensory deficits to significant loss, and the variable timeline for spontaneous neurological recovery, which can span from hours to months [15, 22,...
Interneurons near the lesion level can be recruited to form a relay circuit that may bypass the injury epicenter after SCI.194Courtine et al. found that a retrograde tracer can be transported from below the injury site to above the injury site in a T12 and T7 cross-hemisection rat model. ...
(days 1–7): Surgical procedure: Decompression, discectomy, fusion; single or multi-level Accelerometry: Time spent walking, step count, time spent in sedentary and active postures, number of walks Pain: Back, leg and wound pain (NRPS) Supervised walking: Patient/physiotherapist reported Post-...
Spinal cord injury (SCI) leads to loss of motor and sensory function below the injury level and imposes a considerable burden on patients, families, and society. Repair of the injured spinal cord has been recognized as a global medical challenge for many
was identified in the patients who experienced clumping or enhancement of the cauda equina nerve roots. Figure1shows the pre-infusion and follow-up MRI of patient 6, who developed mildly increased clumping of the cauda equina nerve roots at the L4-S1 level. Table3highlights the MRI changes ...
Statistical analysis was performed using ANOVA followed by Tukey’s test (*p < 0.05, **p < 0.01, and ***p < 0.001) Full size image TPME promoted neurogenesis at the injury site To explore the mechanisms underlying rat motor function recovery after SCI at 8 weeks, immuno...
They were maintained for 2-3 weeks at 37°C, to allow time for recovery and maturation after the process of dissociation. This proved crucial for the ability of the neurons to respond to high K+. During the maintenance phase, the culture medium was replaced every 3-4 days. Dorsal root ...
Axonal regeneration serves as the fundamental mechanism for achieving functional recovery after SCI, making it a crucial focus for therapeutic interventions. MSCs possess the ability to modulate the intrinsic regenerative microenvironment at the molecular level, while also regulate the extrinsic inhibitory mi...
the reparability is limited because glial scar formation impedes functional recovery. There is a type of astrocyte that can differentiate into two forms of reactive astrocytes known as ‘A1’ and ‘A2’ astrocytes. A1 astrocytes release cytotoxic chemicals that cause neurons and oligodendrocytes to di...