GFP-labeled spinal cord motor neuron co-expressing NeuN.Sreenivasa R. SankavaramMikael A. SvenssonTomas OlssonLou BrundinClas B. Johansson
After laminectomy at the desired level of the spine, the clip is closed at specific force around the spinal cord to produce an acute injury. The force of clip closure and duration of application can be varied to produce injury of varying severity. (B) Schematic diagram of calibrated ...
a Schematic diagram of the intervertebral window with ligamentum flavum (LF). b Cross-sectional schematics of the LF window. c, d Projection and 3D reconstruction of an in vivo multimodal image stack of the LF window. Green: GFP labeled microglia; Red: blood vessels labeled with Texas Red de...
Local ischemia and hypoxia are the most important pathological processes in the early phase of secondary spinal cord injury (SCI), in which mitochondria are the main target of ischemic injury. Mitochondrial autophagy, also known as mitophagy, acts as a s
Spinal cord injury (SCI) is a significant cause of disability, and treatment alternatives that generate beneficial outcomes and have no side effects are urgently needed. SCI may be treatable if intervention is initiated promptly. Therefore, several treatment proposals are currently being evaluated. Infl...
spinal cord injury;athlete;energy availability;nutrient deficiency;low energy availability;bone mineral density;para athlete;menstrual dysfunction;Female Athlete Triad;Relative Energy Deficiency in Sports (RED-S) 1. Introduction Energy and nutrient availability have been widely studied in able-bodied athletes...
neuroprotective effects.42,43 In the treatment of encephalopathy, exosomes primarily target microglia and neuronal cells.44,45 In this study, immunofluorescence results of PKH67-labeled BMSCs-Exo indicated their presence within the spinal cord injury area and were primarily localized to microglial cells...
In the present specification, the “spinal fluid glycoprotein” refers to a glycoprotein that is expressed in cells of the central nervous system such as the brain and/or the spinal cord, found mainly in spinal fluid, and has a GlcNAc residue at a non-reducing terminus of the sugar chain....
Time-dependent changes in Bolton-Hunter-labeled125I-substance P binding occurred in the dorsal horn of the spinal cord following unilateral adjuvant-induced inflammation in the hindpaw of the rat. Inflammation was characterized by measures of edema and hyperalgesia. Edema and hyperalgesia were both pr...
Immunofluorescence staining of Tuj-1 in injured spinal cord regions showed that the bFGF-HUCMSCs group had more Tuj-1-positive cells in vertical sections than control and HUCMSCs groups (Fig. 7a). Endogenous NSCs were labeled by an anti-Nestin antibody. Nestin and Ki-67 costaining represents...