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Spinal cord injury (SCI) triggers distinct systemic changes in circulating white blood cell (WBC) numbers and phenotype [1,2,3], and is associated with immune infiltration into the lesion site [4,5,6]. The inflammatory response itself has long been recognised as a therapeutic target in SCI...
To examine the temporal dynamics of SC cells during regeneration, we determined the numbers and relative proportions of nuclei within each coarse cluster in the integrated dataset (Figs. 1D and S1I). Neurons A, which comprised 32% of the nuclei harvested from uninjured SCs, comprised 18% of ...
Epidural electrical stimulation (EES) of lumbosacral sensorimotor circuits improves leg motor control in animals and humans with spinal cord injury (SCI). Upper-limb motor control involves similar circuits, located in the cervical spinal cord, suggesting that EES could also improve arm and hand moveme...
Labeled peptide samples were combined 1:1, desalted using Thermo desalting spin column, and dried via vacuum centrifugation. The dried TMT-labeled sample was fractionated using high pH reversed phase HPLC [118]. Briefly, the samples were offline fractionated over a 90-min run, into 96 fractions...
Spinal manipulation (SM) has been claimed to change anatomy, either in structure or position, and that these changes may be the cause of clinical improvements. The aim of this systematic review was to evaluate and synthesise the peer-reviewed literature
In a retrospective study of 130 patients injured between birth and the age of 21 years, 97% of patients injured before the growth spurt developed scoliosis compared to 52% injured after adolescent growth spurt (Dearolf et al., 1990). These numbers were further validated by Apple and ...
be construed as limited to the embodiments set forth herein; rather these embodiments are provided so that the disclosure can be thorough and complete, and as part of the effort to convey the scope of the invention to those skilled in the art. Like numbers refer to like elements throughout....
In an anatomical study of this kind it is not possible to give any clear indication of the pattern of blood flow through the arteries of the spinal cord and it is imposs ible to give a confident prediction of the position of the feeding vessels or an indication of their numbers in ...
nor lesions made to the dorsal nerve roots. An incision (~20 mm in length) was made along the dorsal midline and skeletal muscles retracted to expose the vertebral column. The identical anaesthesia protocol was used as for DRG-lesioned mice and animals were sutured using the same protocols...