Methods Animals used and experimental groups All experimental protocols were approved by the Animal Care Committee at the Toronto Western Research Institute in accordance with the policies of theGuide to the Care and Use of Experimental Animalsas per the Canadian Council of Animal Care. Female, adult...
Few patients are amenable to an intrathecal delivery route for chronic care, meaning that an isoform-selective approach is necessary to achieve the benefits of spinal Hsp90 inhibition. One potential concern in adopting these isoform-selective inhibitors for therapy is the potential for on-target side...
ThisSMNcopy-number caller can be used to identify both carrier and affected status of SMA, enabling SMA testing to be offered as a comprehensive test in neonatal care and an accurate carrier screening tool in GS sequencing projects. Similar content being viewed by others Open access07 January 20...
The main findings of this study are that (1) both CART(55-102) and CART(62-102) are present in the spinal dorsal horn and co-exist with DPP4 in lamina I and II; (2) CART(55-102) does not alter the acute nociceptive threshold but shows an antihyperalgesic effect in carrageenan-indu...
The protocols used in this study complied with the regulations of the Institutional Animal Care and Use Committee at the Northeastern University (protocol 21-0824R, date of approval 20 August 2021). Informed Consent Statement Not applicable. Data Availability Statement All of the data is provided ...