Sphingosine 1-phosphate receptor (S1P) and S1PR regulate the trafficking of neutrophils and some cells, which has great effects on immune systems, lung tissue, and liver tissue. Presently, many related reports have proved that S1PR has a strong effect on the migration of lymphocytes, tumor ...
Sphingosine 1-phosphate (S1P), which acts via G protein-coupled S1P receptors (S1PRs), is a bioactive lipid essential for vascular integrity and lymphocyte trafficking. The S1P–S1PR signalling axis is a key component of the inflammatory response in autoimmune rheumatic diseases. ...
ARTICLES Sphingosine-1-phosphate receptor-1 (S1P1) is expressed by lymphocytes, dendritic cells, and endothelium and modulated during inflammatory bowel disease T Karuppuchamy1,2, E-h Behrens1,2, P Gonza´lez-Cabrera3, G Sarkisyan3, L Gima1,2, JD Boyer1,2, G Bamias4, P Jedlicka5, ...
Nitric oxide is one of the major endothelial-derived vasoactive factors that regulate blood pressure (BP), and the bioactive lipid mediator S1P (sphingosine-1-phosphate) is a potent activator of endothelial nitric oxide synthase through G protein-coupled receptors. Endothelial-derived S1P and the aut...
Knockdown of the sphingosine-1-phosphate receptor S1PR1reduces pain behaviors induced by local inflammation of the rat sensory ganglionKnockdown of the sphingosine-1-phosphate receptor S1PR1reduces pain behaviors induced by local inflammation of the rat sensory gangliondoi:10.1016/j.neulet.2012.03.019Sp...
Sphingosine 1-phosphate receptors (S1PRs) are a family of G-protein coupled receptors composed of subtypes S1PR1鈥 5 and activated by the endogenous ligand ... AJ Pritchard,KK Dev - 《Future Neurology》 被引量: 7发表: 2013年 Sphingosine-1-phosphate receptor 1 as a prognostic biomarker and ...
The Sphingosine 1-Phosphate Axis: an Emerging Therapeutic Opportunity for Endometriosis Fengrui Zhang Yuan Lu Reproductive Sciences(2023) Visualizing Sphingosine-1-Phosphate Receptor 1(S1P1) Signaling During Central Nervous System De- and Remyelination ...
Sphingosine 1-phosphate receptor S1P1 S1pr1 GPCR Cardiomyocyte Noncompaction Heart development 1. Introduction Sphingosine 1-phosphate (S1P) is a bioactive lipid that acts via five G protein-coupled receptors (GPCRs) called S1P1-S1P5 (Blaho and Hla, 2011, Mutoh et al., 2012). The S1P1 rece...
Apoptotic cells enhance sphingosine-1-phosphate receptor 1 dependent macrophage migrationMacrophage activationPeritonitisResolution of inflammationSphingolipidsZymosanThe lipid sphingosine-1-phosphate (S1P) is a chemokine for a variety of immune cells including lymphocytes and monocytes. Migration toward S1P is ...
For example, application of laminar shear stress (LSS) upregulates the expression of S1P receptor 1 (S1PR1). However, the role of fluid forces that arise at vessel bifurcations in regulating the effect of S1P remains unclear. To address this gap in knowledge, we developed a novel microfluidic...