Sphingosine-1-phosphate receptor 1 (S1PR1) promotes tumour cell survival, invasion, anti-apoptosis, metastasis and radio/chemo-resistance in various cancers. However, the expression pattern and prognostic implications of S1PR1 in urothelial carcinoma remain unclear and thus were addressed here. Tissue ...
Sphingosine 1-phosphate (S1P), which acts via G protein-coupled S1P receptors (S1PRs), is a bioactive lipid essential for vascular integrity and lymphocyte trafficking. The S1P–S1PR signalling axis is a key component of the inflammatory response in autoimmune rheumatic diseases. ...
Sphingosine 1-phosphate receptor 1 regulates cell-surface localization of membrane proteins in endothelial cellsThe endothelial cell (EC) barrier disruption has been implicated in vascular leakage and pulmonary edema. Many reports have shown that the EC barrier dysfunction is regulated by the sphingosine...
ARTICLES Sphingosine-1-phosphate receptor-1 (S1P1) is expressed by lymphocytes, dendritic cells, and endothelium and modulated during inflammatory bowel disease T Karuppuchamy1,2, E-h Behrens1,2, P Gonza´lez-Cabrera3, G Sarkisyan3, L Gima1,2, JD Boyer1,2, G Bamias4, P Jedlicka5, ...
Knockdown of the sphingosine-1-phosphate receptor S1PR1reduces pain behaviors induced by local inflammation of the rat sensory ganglionKnockdown of the sphingosine-1-phosphate receptor S1PR1reduces pain behaviors induced by local inflammation of the rat sensory gangliondoi:10.1016/j.neulet.2012.03.019Sp...
Sphingosine 1-phosphate receptors (S1PRs) are a family of G-protein coupled receptors composed of subtypes S1PR1鈥 5 and activated by the endogenous ligand ... AJ Pritchard,KK Dev - 《Future Neurology》 被引量: 7发表: 2013年 Sphingosine-1-phosphate receptor 1 as a prognostic biomarker and ...
The Sphingosine 1-Phosphate Axis: an Emerging Therapeutic Opportunity for Endometriosis Fengrui Zhang Yuan Lu Reproductive Sciences(2023) Visualizing Sphingosine-1-Phosphate Receptor 1(S1P1) Signaling During Central Nervous System De- and Remyelination ...
Nitric oxide is one of the major endothelial-derived vasoactive factors that regulate blood pressure (BP), and the bioactive lipid mediator S1P (sphingosine-1-phosphate) is a potent activator of endothelial nitric oxide synthase through G protein-coupled receptors. Endothelial-derived S1P and the aut...
sphingosine 1-phosphate receptorSphingosine 1-phosphate receptors (S1PRs) are a family of G-protein coupled receptors composed of subtypes S1PR1鈥 5 and activated by the endogenous ligand sphingosine 1-phosphate. S1PRs are modulated by the recently approved oral therapy for relapsing鈥搑emitting ...
Sphingosine 1-phosphate Sphingosine 1-phosphate receptor S1P1 S1pr1 GPCR Cardiomyocyte Noncompaction Heart development 1. Introduction Sphingosine 1-phosphate (S1P) is a bioactive lipid that acts via five G protein-coupled receptors (GPCRs) called S1P1-S1P5 (Blaho and Hla, 2011, Mutoh et al.,...