We discuss essential conceptual and practical considerations for an adequate establishment and use of spheroid-based drug screening platforms and also provide a list of human carcinoma cell lines, partly on the basis of the NCI-DTP 60-cell line screen, that produce treatable spheroids under ...
哪位大神能翻译一下这个spheroid-based drug screen
Hence, this approach allows to efficiently examine the efficacy of drug combinatorics or new compounds in 3D cell culture. Additionally, it may provide a valuable instrument to screen for new and individualized systemic therapeutic strategies in second and third line treatment of solid malignancies ...
Friedrich J, Seidel C, Ebner R, Kunz-Schughart LA: Spheroid-based drug screen: considerations and practical approach. Nat Protoc. 2009, 4: 309-324. 10.1038/nprot.2008.226. Article PubMed CAS Google Scholar Weiswald LB, Guinebretiere JM, Richon S, Bellet D, Saubamea B, Dangles-Marie ...
正如我们所知道的,地球是一个椭球体。 权威例句 Spheroid chromatin units (v bodies). Spheroid Chromatin Units (ν Bodies) Spheroid Chromatin Units (nu Bodies) Spheroid Chromatin Units (谓 Bodies) Spheroid Chromatin Units (ν Bodies) Spheroid-based drug screen: considerations and practical approach ...
Friedrich J, Seidel C, Ebner R, Kunz-Schughart LA: Spheroid-based drug screen: considerations and practical approach. Nat Protoc. 2009, 4: 309-324. 10.1038/nprot.2008.226. Article PubMed CAS Google Scholar Weiswald LB, Guinebretiere JM, Richon S, Bellet D, Saubamea B, Dangles-Marie ...
The cell spheroids were subjected to drug toxicity screening in cryogel based open-ended platforms. It was observed that the spheroids were more resistant to anticancer drugs, as compared to 2D and 3D controls, with approximately 11%–67% increase in the IC50values of tamoxifen and paclitaxel. ...
3D tumor spheroids, also known as cancer spheroids, are composed of tumor cells in various proliferative and metabolic states and have demonstrated to mimic complex physiological tumor processes like tumorigenesis, microenvironment, heterogeneity, and tumor-immune interaction. Testing cancer drug c...
developing efficient drug screening method based on more in vivo like tumor tissue is an urgent need to predict the toxicity and efficacy of candidate drugs. In comparison to 2D planar tumor model, the 3D multicellular tumor spheroid (MTS) can better simulate the spatial structure, hypoxia and ...
Generation of multicellular tumor spheroids with microwell-based agarose scaffolds for drug testing. PLoS ONE. 2015;10:e0130348-8. Article PubMed PubMed Central Google Scholar Chen M, Vial M-L, St John JA. 3D-tips: user-friendly mesh barrier pipette tips for 3D-spheroid culture. J Biol ...