herpes simplex virus 1double-stranded RNA-dependent protein kinase2’5’-oligoadenylate synthetase 2atopic dermatitiseczema herpeticumIFN-γPrevious studies have found specificity protein (Sp) 1 transcription factor in the viral replication machinery and postulated that Sp1 was required for viral ...
When probes were incubated with nuclear extracts from human SH-SY5Y or murine N2a cells, the formation of slower migrating DNA-protein complexes was observed (Fig. 1, B and C, lane 1). The presence of Sp1 was revealed through supershift competition (Fig. 1, B and C, lane 3). ...
胰腺癌是发达国家和地区癌症相关死亡的主要原因之一,在中国的发病率也越来越高.Sp1(specificity protein1)是一个序列特异的DNA结合蛋白,在调节肿瘤细胞生长,分化,转移及血管生成过程中起重要作用.研究发现,Sp1在胰腺癌的发生,发展中发挥重要作用,可能是一个新的生物学标志,标识胰腺癌的侵袭性生物学行为,并为胰腺癌的...
Specificity protein 1-mediated ACSL4 transcription promoted the osteoarthritis progression through suppressing the ferroptosis of chondrocytes 来自 NCBI 喜欢 0 阅读量: 13 作者:W He,X Lin,K Chen 摘要: Chondrocytes are the main cell damage type involved in the occurrence and development of ...
ligand Trail by specificity protein 1-dependent upregulation of death receptor 5 A Fassl1,3, KE Tagscherer1, J Richter1, J De-Castro Arce2, C Savini2, F Rösl2 and W Roth*,1 The Notch1 signaling pathway contributes to tumorigenesis by influencing differentiation, proliferation and ...
MicroRNA-320 inhibits cell proliferation, migration and invasion in retinoblastoma by targeting specificity protein 1 Research into the expression and function of microRNAs (miRNAs/miR) in human cancer has provided novel insights into the molecular mechanisms underlying ca... Y Zhao,S Zhang,Y Zhang ...
We found that Res interacts with specificity protein 1 (Sp1). The IC50 for Res was 17 M in MSTO-211H cells. Cell viability was decreased and apoptotic cell death was increased by Res (0-60 M). Res increased the Sub-G1 population in MSTO-211H cells and significantly suppressed Sp1 ...
Furthermore, miR- 335 might suppress gastric cancer invasion and metastasis by targeting Bcl-w and specificity protein 1 (SP1). Taken together, our results provide evidence that miR-335 might function as a metastasis suppressor in gastric cancer by targeting SP1 directly and indirectly through the...
Fibrosis Plasminogen activator inhibitor type-1 (PAI-1) Activator protein-1 (AP-1) Specificity protein 1 (SP-1) SMAD pathway 1. Introduction Kidney fibrosis is caused by various factors including diabetes, high blood pressure, glomerulonephritis, and age-related chronic kidney disease [1], [2]...
SIRT1 overexpression attenuated p66shc expression but enhanced GDF1 protein expression, while SIRT1 depletion exerted the opposite effect. Both the antioxidants N-acetylcysteine and folic acid reversed the arsenic-mediated repression of Sp1, GDF1 and SIRT1. Moreover, wild-type p66shc overexpression ...