Dual-specificity phosphatase 13Dual-specificity phosphatase 4Epithelial-mesenchymal transitionExtracellular signal-regulated kinaseTransforming growth factor β1Transforming growth factor-beta (TGFβ) proteins induce an epithelial-mesenchymal transition (EMT) programme that is associated with increased invasive and...
Dual-specificity Protein Phosphatases DSP; Dual specificity protein phosphatase; Mammalian class I dual-specificity cysteine-based phosphatase (DSP); MAPK phosphatase; MKP; Dual-specificity Protein Tyrosine Phosphatase (PTP); DSPase In... S Prabhakar,S Asuthkar,AJ Tsung,... 被引量: 0发表: 0年...
Dual-specificity protein phosphatases comprise a protein phosphatase subfamily with selectivity towards mitogen-activated protein (MAP) kinases, also named MKPs, or mitogen-activated protein kinase (MAPK) phosphatases. As powerful regulators of the intensity and duration of MAPK signaling, a relevant role...
Structure, Mechanism, and Specificity of Protein-Tyrosine Phosphatases Zhong-YinZhang, inCurrent Topics in Cellular Regulation, 1997 BStructures of VHR and Low MrPhosphatase The VH1-like dual-specificityphosphatasesand the lowMrphosphatases display littleamino acidsequence identity with the classic...
DSP-12 and DSP-13 dual-specificity phosphatases 优质文献 相似文献 参考文献Protein phosphatase complement in rice: genome-wide identification and transcriptional analysis under abiotic stress conditions and reproductive development p pBackground/p pProtein phosphatases are the key components of a number of...
A serine/threonine protein phosphatase 2A, which regulates c-Jun N-terminal kinase (JNK) 1 and GR-Ser 226 signaling, is involved in this mechanism. Here, we further explored protein kinase dual-specificity phosphatases (DUSPs) with the ability to dephosphorylate JNK, and identified DUSP4 as ...
Dual-specificity phosphatases (DUSPs) are a subclass of protein tyrosine phosphatases (PTPs) that interact with and regulate mitogen-activated protein kinases (MAPKs). DUSPs can positively or negatively control immune responses in cancers, infectious dis
et al. Crystal structure of human TMDP, a testis-specific dual specificity protein phosphatase: implications for substrate specificity. Proteins 66, 239–245 (2007). Article CAS PubMed Google Scholar Owens, D. M. & Keyse, S. M. Differential regulation of MAP kinase signalling by dual-...
Dual-specificity kinases (DSK; or Ser/Thr/Tyr kinases) phosphorylate their substrates on serine, threonine, and/or tyrosine residues. Dual-specificity kinases intervene in the regulation of cell growth, differentiation, and apoptosis. Dual-specificity kinases include, at least, members of the superfam...
dual-specificity protein phosphatase ERK: extracellular-signal regulated kinase JNK: c-Jun amino-terminal kinase MAPK: mitogen-activated protein kinase MEF: mouse embryo fibroblast MKK or MEK: MAPK kinase MKKK or MEKK: MAPK kinase kinase MKP: MAP kinase phosphatase NSCLC: non-small cel...