The time-course of DUSP2 protein expression elicited by P2Y13 receptor activation correlates well with the recovery of low basal levels of the phosphorylated form of nuclear p38 (Fig. 5) (Morente et al., 2014).
Protein phosphataseDual-specificity protein phosphatases participate in signal transduction pathways inactivating mitogen-activated protein kinases (MAP kinases). These signaling pathways are of critical importance in the regulation of numerous biological processes, including cell proliferation, differentiation and ...
et al. Crystal structure of human TMDP, a testis-specific dual specificity protein phosphatase: implications for substrate specificity. Proteins 66, 239–245 (2007). Article CAS PubMed Google Scholar Owens, D. M. & Keyse, S. M. Differential regulation of MAP kinase signalling by dual-...
Although dual-specificity phosphatase 5 (DUSP5), which inactivates extracellular signal-regulated kinase (ERK), suppresses tumors in several types of cancer, its functional roles remain largely unknown. Here, we show that DUSP5 is induced during lipopoly
Over-expression of this dual specificity phosphatase inhibited cell death initiated by MAPKKK伪. Point mutations in the conserved phosphatase active site were made, but the mutated phosphatases were still able to inhibit the kinase induced cell death....
英文名称:Dual Specificity Protein Phosphatase 1/6 Inhibitor 品牌:瀚香生物 分子式:C22H23NO 货号:BCP31565 产地:国产 纯度:98% 是否进口:否 ***瀚香生物产品特别注意*** 1、全场产品全国免运费。 2、产品价格和图片仅供参考,具体价格和产品问题请咨询客服,欢迎来电咨询! 3、公司有严格的质量控制体系,每个...
英文名:PTEN, phosphorylated (T366) (PTEN, MMAC1, TEP1, Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, Mutated in multiple advanced cancers 1, Phosphatase and tensin homolog) (MaxLight 550) 中文名: CBNumber:CB04951861 分子式: 分子量:0 MOL ...
Dual-specificity kinases (DSK; or Ser/Thr/Tyr kinases) phosphorylate their substrates on serine, threonine, and/or tyrosine residues. Dual-specificity kinases intervene in the regulation of cell growth, differentiation, and apoptosis. Dual-specificity kinases include, at least, members of the superfam...
Combinatorial control of the specificity of protein tyrosine phosphatases. Curr. Opin. Cell Biol. 13, 182–195 (2001). CAS PubMed Google Scholar Zhang, Y. et al. Regulation of innate and adaptive immune responses by MAP kinase phosphatase 5. Nature 430, 793–797 (2004). The first paper...
DUSP1/MKP-1 was the first of the dual-specificity MKPs to be characterised and was initially discovered as a growth factor or stress-inducible gene encoding a nuclear protein with homology to VH1, the prototypic dual-specificity protein phosphatase encoded by vaccinia virus [7,8]. Initially cha...