An Example of Specific AIMS in NIH StyleSchlumberger, ESuiro, LDeborde, a S
(IVs) are strongly associated with the exposure of interest; (2) independence—there are no confounders in the association between IVs and the outcome of interest; and (3) exclusion restriction—instruments are not associated to the outcome other than via exposure, for example, through horizontal...
This approach aims to decrease the overrepresentation of certain TE families, thereby fostering a more balanced representation within our model. We also removed TE families with too little training sample (less than 50 samples) to focus on more representative TE families. Such balanced representation...
Query reformulation aims to reduce query-document mismatch and retrieve more relevant documents for better system performance. Query expansion only focuses on expanding the query using words or phrases with a similar meaning or some other statistical relation to the set of relevant documents in order ...
(Fig.3). Phagocytosis and cell death were primarily enriched in NRs and ODCs, while all cell types had enrichment of at least one pathway related to immunity and inflammation. For example, the NF-kappa B signaling pathway was significantly enriched in male A2B5+cells and MGs, and both ...
K-means51clustering aims to partition samples into different clusters with high intra-cluster similarity. The identified clusters can then serve as a basis for comparing typical groups or sample profiles. The method represents clusters as centroids (cluster centers), and iteratively refines them by ...
In terms of regulation specific to individual cell types, scHumanNet [23] aims to generate specialized gene regulatory networks (GRNs) for individual cell types by leveraging the information contained in the HumanNet reference interactome [24] and single-cell expression data. Recently, scMTNI [25]...
Backgroundl Aims: Some of the mutant forms of cellular proteins not only lose their function, but also cause diseases by their toxic effects. One of the challenging tasks in the field of gene therapy will be “gene replacement” accomplished by inhibiting mutant gene expression and providing nor...
Using patient cluster-specific DEGs as input (Additional file 2: Figure S7C, Additional file 9: Table S8), we searched for compounds that evoke a reverse signature in human cells via the NIH Library of Integrated Network-Based Cellular Signatures (iLINCS) [87] and the Broad Institute’s Rep...
Journal of the International Society of Sports Nutrition (2021) 18:27 Page 13 of 20 usage of key dietary supplements; this summary aims to highlight supplements that have been studied in women and have been shown to be efficacious. Additionally, some of the supplements that have been discussed...