An Example of Specific AIMS in NIH StyleSchlumberger, ESuiro, LDeborde, a S
The disease-specific accumulation of pathological proteins has long been the major focus of research in neurodegenerative diseases (ND), including Alzheimer’s disease (AD) and related dementias (RD), but the recent identification of a multitude of genetic risk factors for ND in immune-associated ...
and multi-copy amplifications on chromosome 16. Of course, given the limitations of bulk sequencing compared to single-cell, there are some CNAs that are missed by HATCHet2. For example, HATCHet2 does not recover the mirrored-subclonal event on chr3 that affects only3.3%of cells. These...
Query reformulation aims to reduce query-document mismatch and retrieve more relevant documents for better system performance. Query expansion only focuses on expanding the query using words or phrases with a similar meaning or some other statistical relation to the set of relevant documents in order ...
For example, Non-Asian LUADs had a larger number of sex-biased genes compared with Asian LUADs. Sex differences in immune microenvironment have been found in multiple types of cancer. For example, female patients with lung squamous cell carcinoma had significantly higher abundance of activated CD4...
K-means51clustering aims to partition samples into different clusters with high intra-cluster similarity. The identified clusters can then serve as a basis for comparing typical groups or sample profiles. The method represents clusters as centroids (cluster centers), and iteratively refines them by ...
Different from PRIAM, BrEPS aims at defining minimal sequence patterns for one or more EC numbers. In the first step the enzyme sequences in the Swiss- Prot part of the UniprotKB are identified and sorted into three categories. The enzyme sequences are then compared by an all-vs.-all ...
Especially in western civilizations, immune diseases that are driven by innocuous (auto- or allo-) antigens are gradually evolving to become pandemic threats. A particularly poignant example is type 1 diabetes, where young children are confronted with th
(Fig.3). Phagocytosis and cell death were primarily enriched in NRs and ODCs, while all cell types had enrichment of at least one pathway related to immunity and inflammation. For example, the NF-kappa B signaling pathway was significantly enriched in male A2B5+cells and MGs, and both ...
Another, curious, example isBC051142,a gene that according to NCBI database is highly testis-specific (seehttps://www.ncbi.nlm.nih.gov/gene/?term=BC051142), and whose human homolog,Testis Expressed Basic Protein 1(TSBP1), has been associated with hypogonadism (https://www.genecards.org/...