Specialized pro-resolving lipid mediators in the inflammatory response: An update. Biochim Biophys Acta 2010;1801(12):1260-1273.Bannenberg, G., and C. N. Serhan. 2010. Specialized pro-resolving lipid mediators i
SPMs are lipid mediators that are part of a larger family of pro-resolving molecules, which includes proteins and gases, that together restrain inflammation and resolve the infection. These immunoresolvents are distinct from immunosuppressive molecules as they not only dampen inflammation but also ...
We are submitting the review article entitled “Specialized pro-resolving lipid mediators: a new class of non-immunosuppressive and non-opioid analgesic drugs” of Fattori V et al. to be evaluated for publication in Pharmacological Research. The authors declare no conflict of interest. All financial...
Here, we use targeted mass spectrometry to identify specialized pro-resolving lipid mediators (SPM) in histologically-defined stable and vulnerable regions of human carotid atherosclerotic plaques. The levels of SPMs, particularly resolvin D1 (RvD1), and the ratio of SPMs to pro-inflammatory ...
Inflammation is an essential mechanism of various diseases. The development and resolution of inflammation are complex immune-modulation processes which induce the involvement of various types of immune cells. Specialized pro-resolving lipid mediators (S
the discovery that resolution is an active process introduced by the biochemical synthesis of specific proresolving molecules [13], among which are lipid mediators derived from ω-6 and ω-6 fatty acids that were dubbed “Specialized Pro-resolving lipid Mediators (SPM) by its discoverer CN Serhan...
Biosynthesis of pro-resolving lipid mediators in humans is far from understood. Here, we could show that SPMs formed in human neutrophils are dominated by the dihydroxylated ARA and DHA derivatives 5(S),15(S)-diHETE and RvD5 derived from the dioxygenation by 5-LO and 15-LO. In contrast,...
Resolution of inflammation is mediated by a group of newly discovered lipid mediators called specialized pro-resolving lipid mediators (SPMs). Accumulating evidence suggests that SPMs decrease leukocyte infiltration, enhance efferocytosis, reduce local neuronal injury, and decrease both oxidative stress and ...
(ARA) and a derivative thereof, wherein the preparation is suitable for increasing a formation of one or more specialized pro-resolving lipid mediators (SPM) by microorganisms in a gastrointestinal tract of humans or animals, and wherein the omega-3 or omega-6 fatty acid component comprises an...
The present invention relates to a specialized pro-resolving lipid mediator comprising maresins, D-series resolvins, E-series resolvins, protectins or lipoxins, or a combination the