Basil MC, Levy BD. Specialized pro-resolving mediators: endogenous regulators of infection and inflammation. Nat Rev Immunol (2016) 16(1):51-67. doi:10.1038/nri.2015.4Basil, M.C., Levy, B.D., 2016. Specialized pro-resolving mediators: endogenous regulators of infection and inflammation. Nat...
Specialized pro-resolving mediators as a therapeutic approach to neuropathic pain Acute inflammation is a self-limited protective response to infection or tissue damage that is controlled by a complex network of regulatory mechanisms. Under normal conditions, the inflammatory cascade is suppressed once its...
We are submitting the review article entitled “Specialized pro-resolving lipid mediators: a new class of non-immunosuppressive and non-opioid analgesic drugs” of Fattori V et al. to be evaluated for publication in Pharmacological Research. The authors declare no conflict of interest. All financial...
J.D. is an inventor on patents related to the composition of matter and/or use of pro-resolving mediators some of which are licensed by Brigham and Women’s Hospital or Queen Mary University of London for clinical development. E.A.G. is an inventor on patents related to the use of pro...
This invention provides the use of specialized pro-resolving mediators (SPMs) for use as melanocyte growth promoters and pro-survival factors. More particularly, the SPM compositions are suitable for promoting melanocyte growth and/or survival to prevent depigmentation of melanocytes and/or promoting re...
Inflammation is an essential mechanism of various diseases. The development and resolution of inflammation are complex immune-modulation processes which induce the involvement of various types of immune cells. Specialized pro-resolving lipid mediators (S
Specialized pro-resolving mediators The end of inflammation involves a switch from pro-inflammatory to pro-resolution mediators including the actions of a pool of molecules. The SPM derived from omega-3 fatty acids enhance the host immune response promoting the resolution of inflammation, and are dis...
the discovery that resolution is an active process introduced by the biochemical synthesis of specific proresolving molecules [13], among which are lipid mediators derived from ω-6 and ω-6 fatty acids that were dubbed “Specialized Pro-resolving lipid Mediators (SPM) by its discoverer CN Serhan...
The present invention relates to a specialized pro-resolving lipid mediator comprising maresins, D-series resolvins, E-series resolvins, protectins or lipoxins, or a combination the
(ARA) and a derivative thereof, wherein the preparation is suitable for increasing a formation of one or more specialized pro-resolving lipid mediators (SPM) by microorganisms in a gastrointestinal tract of humans or animals, and wherein the omega-3 or omega-6 fatty acid component comprises an...