The present invention further provides a method for evaluating L1 elements as markers of disease genes, susceptibility factors, pathogenic triggers or mediators of complex diseases, including systemic and organ targeted autoimmune diseases. Additionally, the present invention discloses the use of L1 eleme...
Intracellular pro-inflammatory cytokines; The central mediators of osteoclast activity; appears, in part, to mediate the bone resorption–inducing effects of TNF-a and IL-l and osteoprotegerin (OPG); B lymphocytes and hepatocytes are its principal targets; Primary effects include B-cell ...
Besides these basic metabolic regulatory mechanisms and the effects of GH itself, the presence of inflammatory mediators also impacts the level of functional surface exposed GHR. A series of studies have shown an effect on GH-induced signaling by some of the key inflammatory mediators in IBD ...