tendency type, green: short-range; yellow: medium; red: long-range. PDAC: pancreatic ductal adenocarcinoma; SCC: squamous cell carcinoma.dThe interaction type proportion in short-range and long-range interactions. Color for interaction type, blue: secreted signaling type interaction; orange: cell-c...
We propose that the spatial distance suggests the interaction tendency of different cell types, thus could be used for evaluating cell-cell interaction tools.We benchmark 16 cell-cell interaction methods by integrating scRNA-seq with ST data. We characterize cell-cell interactions into short-range ...
Cell-cell Interactions and Communication Analysis The pipeline integrates the RNA-seq and PPI datasets by using the analysis setups. It generates an interaction space containing an instance for each sample/cell type, containing the values assigned to each protein in the PPI list given the setups ...
With the aim to present a more general approach to the problem of extracting reliable quantitative descriptors from the motility and cell-cell interaction phenomena, we investigated the effect of both temporal and spatial resolutions on cell tracking software (see Supplementary Text S1) and related ki...
juxtacrine interactions, cell–cell junction formation or non-cell autonomous mechanisms in neurodegenerative disorders. The analysis of the proteome in pseudopods begins to illuminate some of the unique events that are triggered in Schwann cells by neuronal signals. Overall, the interaction with ...
一、SummarySingle-cell technologies have revealed the complexity of the tumour immune microenvironment with unparalleled resolution. Most clinical strategies rely on histopathological stratifcation …
Population spatial structure may be critical for this problem because it influences the extent of interaction between cooperative and non-cooperative individuals. It is difficult for cooperative cells to succeed in competition if they become mixed with non-cooperative cells, which can exploit the public...
The spread of a virus--whether in a human population, computer network or cell-to-cell--is closely tied to the spatial (graph) topology of the interactions... School of Electrical Engineering and Computer Science, Washington State University, USA - 《Iet Systems Biology》 被引量: 146发表: ...
Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous malignancy characterized by varied responses to treatment and prognoses. Understanding the metabolic characteristics driving DLBCL progression is crucial for developing personalized therapies. This
3f,g) and to removal of the interaction terms from the linear model (Supplementary Fig. 2). The spatial effect on model performance varies between target cell types, suggesting that cell-type-specific molecular mediators of cell–cell dependency are captured (Supplementary Fig. 3). NCEMs can ...