Among mitochondrial respiratory parameters, the spare respiratory capacity (SRC) represents a particularly robust functional parameter to evaluate mitochondrial reserve. We provide an overview of potential SRC mechanisms and regulation with a focus on its particular significance in cancer cells....
Spare respiratory capacity (SRC) was defined as the difference between basal and maximum respiration. Immunocytochemical staining Staining was performed as described recently Cells were seeded in a 24-well plates at 2 × 104 cells per well on coverslips and cultured for one day. Afterwards ...
Spare Respiratory Capacity Rather Than Oxidative Stress Regulates Glutamate Excitotoxicity after Partial Respiratory Inhibition of Mitochondrial Complex I ... Yadava N. and Nicholls D. G. ( 2007 ) Spare respiratory capacity rather than oxidative stress regulates glutamate excitotoxicity after partial respirat...
Spare respiratory capacity may also allow additional metabolic scope for energy dissipation, potentially offering new therapeutic targets for the treatment of metabolic disease. 展开 关键词: Humans Cells, Cultured Cytochromes c1 Adenosine Triphosphate Glucose PPAR gamma Oxidative Phosphorylation Adipocytes ...
Simon M. BellUniversity of Sheffield Sheffield United KingdomMatteo De MarcoUniversity of Sheffield Sheffield United KingdomKaty BarnesUniversity of Sheffield Sheffield United KingdomPamela ShawUniversity of Sheffield Sheffield United KingdomLaura Ferraiuolo...
Spare respiratory capacity, oxidative stress and excitotoxicity. Bio- chem Soc Trans 2009; 37(Pt 6): 1385-1388.Milatovic, D.; Zaja-Milatovic, S.; Gupta, R.C. Oxidative Stress and Excitotoxicity: Antioxidants from Nutraceuticals. ... D Milatovic,S Zaja-Milatovic,RC Gupta - 《Nutraceut...
Spare respiratory capacity may also allow additional metabolic scope for energy dissipation, potentially offering new therapeutic targets for the treatment of metabolic disease.FASEB Journal
AML cells have low spare reserve capacity in their respiratory chain that renders them susceptible to oxidative metabolic stress. Blood 2015; 125:2120-30.Sriskanthadevan, S., Jeyaraju, D. V., Chung, T. E., Prabha, S. et al., AML cells have low spare reserve capacity in their ...
G. Nicholls, "Bioenergetic analysis of isolated cerebrocortical nerve terminals on a microgram scale: spare respiratory capacity and stochastic mitochondrial failure.," J. Neurochem., vol. 109, no. 4, pp. 1179- 91, May 2009.Choi SW, Gerencser AA, Nicholls DG. Bioenergetic analysis of ...
We found that verbascoside (1) improved mitochondrial function by increasing mitochondrial spare respiratory capacity; (2) mitigated the decrease in cell viability induced by H2O2 and reduced ROS levels; (3) promoted the phosphorylation of Nrf2 and its nuclear translocation; (4) incre...