2way to initiate sotalol for Atrial Fibrillation, Atrial Flutter, & Ventricular Tachycardia. Potentially shorten hospital stays and individualize treatment Resource Management Potentially increase bed availability, simplify patient management, and shorten loading regimen Consider a fast, efficient way to initiat...
7 (12.7%) patients had significant QTCprolongation during IV loading. ODSL was terminated in 4 patients: symptomatic bradycardia and prolonged QTC(1 pt) and failure of cardioversion (3 pts).42 (76%) of patients remained on sotalol and 32 (58%) maintained sinus rhythm at 30 day follow up....
Introduction:Recently, an intravenous (IV) formulation of sotalol was approved to provide a loading dose before initiating oral sotalol therapy to reduce h... VK Yellepeddi,K Watt,K Ghaffari,... - 《Circulation》 被引量: 0发表: 2023年 Population pharmacokinetics and pharmacodynamics of sotalol ...
We employed a streamlined protocol that was successfully implemented to facilitate the use of IV sotalol loading for atrial arrhythmias. Our initial experience suggests feasibility, safety, and tolerability while reducing hospitalization duration. Additional data are needed to augment this experience as IV...
Method of converting atrial fibrillation to normal sinus rhythm and loading oral sotalol in a shortened time frameThe present invention provides a novel method of converting AF and monitoring normal sinus rhythm using an initial IV dose of sotalol followed by oral sotalol maintenance therapy. This ...
METHOD OF CONVERTING ATRIAL FIBRILLATION TO NORMAL SINUS RHYTHM AND LOADING ORAL SOTALOL IN A SHORTENED TIME FRAMEThe present invention provides a novel method of converting AF and monitoring normal sinus rhythm using an initial IV dose of sotalol followed by oral sotalol maintenance therapy. This ...
METHOD OF CONVERTING ATRIAL FIBRILLATION TO NORMAL SINUS RHYTHM AND LOADING ORAL SOTALOL IN A SHORTENED TIME FRAMEThe present invention provides a novel method of converting AF and monitoring normal sinus rhythm using an initial IV dose of sotalol followed by oral sotalol maintenance therapy. This ...
IV sotalol dose was calculated based on target oral dose as indicated by baseline QTc interval and renal function. Patients' QTc (in sinus) was measured via ECG on 15 minutes intervals and after IV loading completion. Loading was considered complete after second oral dose. All patients were ...
Introduction:Recently, an intravenous (IV) formulation of sotalol was approved to provide a loading dose before initiating oral sotalol therapy to reduce hospitalization days. However, the population pharmacokinetics (PK) of sotalol after administration of an IV loading dose regimen in patients with ...