Sotalol doses for children are based on age and body surface area (height and weight). Your child's dose needs may change if the child gains or loses weight, or is still growing. Use a calibrated measure to administer the correct dose if your child is prescribed sotalol oral solution. ...
Risk of life-threatening ventricular arrhythmias, particularly torsade de pointes (TdP). The risk of TdP can be reduced by adjustment of the sotalol dose according to creatinine clearance and by monitoring the ECG for excessive increases in QTc. (5.1) Bradyarrhythmia, heart block, sick sinus synd...
Introduction:Recently, an intravenous (IV) formulation of sotalol was approved to provide a loading dose before initiating oral sotalol therapy to reduce h... VK Yellepeddi,K Watt,K Ghaffari,... - 《Circulation》 被引量: 0发表: 2023年 Population pharmacokinetics and pharmacodynamics of sotalol ...
The woman received IV magnesium, without effect. She then underwent temporary pacing. Low-dose bisoprolol wa ...doi:10.2165/00128415-200711560-00079Springer International PublishingReactions Weekly
sotalol can only be used if the QT interval is normalized. The highest probability of arrhythmogenic action marked the beginning of treatment and whenever the dose is increased, so it is recommended to increase gradually, with an interval of 2-3 days. The therapy required monitoring of heart ra...
Nonetheless, Sotalol should be used with particular caution if the QTc is greater than 500 msec on-therapy and serious consideration should be given to reducing the dose or discontinuing therapy when the QTc exceeds 550 msec. Due to the multiple risk factors associated with torsade de pointes, ...
Renal clearance (Clr) and intestinal clearance (Cli) of STL enantiomers were assessed in conscious Sprague–Dawley rats (325g, n =4) following administration of a 10mgkg1 IV dose of the racemate. STL enantiomers were predominantly eliminated intact in the urine: Clr for S- and R-STL (26...
Ibutilide fumarate is an intravenous (IV) class III antiarrhy... Annabelle,S,Volgman,... - 《Journal of the American College of Cardiology》 被引量: 612发表: 1998年 Ibutilide. A review of its pharmacological properties and clinical potential in the acute management of atrial flutter and ...
Embodiments of the invention are broadly drawn to methods for determining an optimum dose of an antiarrhythmic drug, for example sotalol. In particular, the method involves titrating the dose of the drug gradually to determine the optimum plasma concentration for a patient, whether the patient has ...
Embodiments of the invention are broadly drawn to methods for determining an optimum dose of an antiarrhythmic drug, for example sotalol. In particular, the method involves titrating the dose of the drug gradually to determine the optimum plasma concentration for a patient, whether the patient has ...