Sorafenib Tosylate又称Sorafenib p-Toluenesulfonate,BAY 54-9085,有效抑制Raf kinases,Raf-1 (IC50=6 nM)、wt BRAF (IC50=22 nM)和V599E突变的BRAF (IC50=38 nM)和VEGFR2(IC50=90 nM(人)、15 nM(鼠))。Sorafenib具有广泛的抗肿瘤活性,在结肠癌,乳腺癌和非小细胞肺癌移植瘤模型中抑制肿瘤细胞增殖和肿瘤生...
Sorafenib tosylate structure CAS No. 475207-59-1 Chemical Name: Sorafenib tosylate Synonyms CL050;Sorafenib &Sorafeni tosylate;SORAFENIB TOSYLATE;Sorafinib mesylate;Sorafenib (Nexavar);Sorafenib TsOH salt;Sorafenib 475207-59-1;Sorafenib tosylate-002;BAY 43-9006;BAY43-9006 CBNumber: CB92131200 ...
产品信息 产品名称 产品编号 规格 价格(元) SorafenibTosylate 52012ES08 5mg 557.00 SorafenibTosylate 52012ES10 10mg 957.00 SorafenibTosylate 52012ES50 50mg 3657.00 产品描述 SorafenibTosylate 又称Sorafe
Sorafenib tosylate 1.2 Synonyms Sorafenib; Sorafenib; Sorafenib; Sorafenib; Sorafenib; 2-Pyridinecarboxamide, 4-[4-[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-; 4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)-N-methylpicolinamide; 4-[4-({[4-Chloro...
Sorafenib tosylate CAS No: 284461-73-0 Sorafenib-d3 CAS No: 1130115-44-4 Sorafenib IMpurity CAS No: 1256817-30-7 SORAFENIB N-OXIDE CAS No: 583840-03-3 Sorafenib Impurity 6 CAS No: 1285533-84-7 Sorafenib 13C D3 CAS No: 1210608-86-8 Sorafenib Impurity 3 CAS No: 284670-98...
Sorafenib Hemi-Tosylate Inchi: 1S/C21H16ClF3N4O3.C7H8O3S/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25;1-6-2-4-7(5-3-6)11(8,9)10/h2-11H,1H3,(H,26,30)(H2,28,29,31);2-5H,1H3,(H,8,9,10)...
Sorafenib tosylatePoloxamer 188Expanded pore structurePoor solubility of anticancer agent presents a significant challenge in drug delivery and necessitates innovative carrier systems for enhanced therapeutic efficacy. The present study aims to develop and characterize a hollow spherical mesoporous alumina nano...
sorafenib tosylate (Nexavar TM ) was a kind gift from Bayer Health Care (West Haven, CT, USA). Stock solutions were prepared in dimethyl sulfoxide (DMSO) and stored at -20℃ until use. Gemcitabine hydrochloride (Gemzar TM ) was bought from Lilly Pharma (Gieβen, Germany). Doxorubi...
其他形式的 “Sorafenib”: Donafenib Sorafenib tosylate Sorafenib-d4 Sorafenib 纯度: 99.89% 产品编号 T0093L 别名索拉菲尼, 索拉非尼, Bay 43-9006Cas号 284461-73-0 Sorafenib (Bay 43-9006) 是一种多激酶抑制剂,抑制 Raf-1、B-Raf、VEGFR2、VEGFR3、VEGFR4、PDGFRβ、FLT3、c-Kit 等 (IC50=6/22/...
FIG. 1: Chemical structure of PHEA-BIB-pButMA copolymer (PBB).FIG. 2: Dissolution profile of free Sorafenib and Sorafenib release from the PBB nanoparticles in SGF for 2 hours (A); SIF for 24 hours (B) and PBS for 24 hours (C). The reported data refer to the mean values±SD (n...