Sorafenib Tosylate又称Sorafenib p-Toluenesulfonate,BAY 54-9085,有效抑制Raf kinases,Raf-1 (IC50=6 nM)、wt BRAF (IC50=22 nM)和V599E突变的BRAF (IC50=38 nM)和VEGFR2(IC50=90 nM(人)、15 nM(鼠))。Sorafenib具有广泛的抗肿瘤活性,在结肠癌,乳腺癌和非小细胞肺癌移植瘤模型中抑制肿瘤细胞增殖和肿瘤生...
[3-(3-methyl-1H-pyrrol-1-yl)-5-(trifluoromethyl)phenyl]-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-, 4-methylbenzenesulfonate (1:1); Sorafenib & its intermediates; Sorafenib (Tosylate); SORAFENIB TOSYLATE (BAY 43-9006 TOSYLATE); Sorafenib Tosylate(Bay 43-9006,Nexavar); Sorafinib ...
Sorafenib tosylate (CAS 475207-59-1) information, including chemical properties, structure, melting point, boiling point, density, formula, molecular weight, uses, prices, suppliers, SDS and more, available at Chemicalbook.
SorafenibTosylate 52012ES50 50mg 3657.00 产品描述 SorafenibTosylate又称Sorafenibp-Toluenesulfonate,BAY 54-9085,Nexavar®,有效抑制Raf kinases,Raf-1 (IC50=6 nM)、wt BRAF (IC50=22 nM)和V599E突变的BRAF (IC50=38 nM)和VEGFR2(IC50=90 nM(人)、15 nM(鼠))。Sorafenib具有广泛的抗肿瘤活性,在结肠癌...
(665 nm/615 nM) × 10,000 for each well. For IC50 generation, Sorafenib tosylate is added before the enzyme initiation. A 50-fold stock plate is made with Sorafenib tosylate serially diluted 1:3 in a 50% DMSO/50% distilled water solution. Final Sorafenib tosylate concentrations range from...
Sorafenib Tosylate (Bay 43-9006, Nexavar) is a small molecular inhibitor of VEGFR, PDGFR, c-Raf and B-Raf with IC50s of 18 nM, 10 nM, 3 nM and 15 nM, respectively. Uses Sorafenib Tosylate (Bay 43-9006) is a multikinase inhibitor of Raf-1, B-Raf and VEGFR-2 with IC50 of 6 nM...
Sorafenib Tosylate (Bay 43-9006, Nexavar) is a multikinase inhibitor of Raf-1, B-Raf and VEGFR-2 with IC50 of 6 nM, 22 nM and 90 nM, respectively. CAS Number: 475207-59-1 Purity: 99% Molecular Weight: 637.03 Molecular Formula: C21H16ClF3N4O3.C7H8O3S Quality Control: HPLC、NMR...
The molecular formula of sorafenib tosylate is C21H16ClF3N4O3 x C7H8O3S and the molecular weight of sorafenib tosylate is 637.0 g/mole. Its structural formula is: : Sorafenib tosylate is a white to yellowish or brownish solid. Sorafenib tosylate is practically insoluble in aqueous media...
Molecular Weight: 637.03 Synonyms: Sorafenib tosylate [USAN];1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-((2-(methylcarbamoyl)pyridin-4-yl)oxy)phenyl)urea mono(4-methylbenzenesulfonate);4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)-N2-methylpyridine-2-carboxamide mono (4-met...
Molecular Weight: 464.82 Elemental Analysis: C, 54.26; H, 3.47; Cl, 7.63; F, 12.26; N, 12.05; O, 10.33 Synonym:BAY 439006; BAY439006; BAY-439006; BAY 439006 Tosylate Salt; BAY 549085; Nexavar; SFN. IUPAC/Chemical Name:4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)-N...