The weakening of crystals, stabilization of the amorphous phase and an increase in solid-state hydrogen bonding are the likely mechanisms for this enhancement. Reductions in Q70% dissolution time were also observed, by a factor of four and seven for ibuprofen:HMPC and ibuprofen:soluplus co-milled...
The present piece of research work is framed for improving the solubility of ketoprofen by forming co-crystal using fumaric acid as a coformer. Co-crystal of ketoprofen and fumaric acid was prepared by simple solvent-assisted grinding method, containing drug and coformer as independent variables and...
Co-solvent enhancement effects MCO2 CO2 molecular weight (g/mol) Ms Solute molecular weight (g/mol) MW Molecular weight (g/mol) N The number of experimental data, dimensionless nCO2 Mole of CO2 nsolute Moles of solute (RXN) P Pressure (MPa) Pc Critical pressure (MPa) Pref Reference pres...
Various techniques of bioavailability enhancement: a review. J Drug Deliv Ther. 2016;6(3):34–41. 19. Kumar S, Singh P. Various techniques for solubility enhancement: an overview. Pharma Innov J. 2016;5(1):23–8. 20. Jouyban A. Review of the cosolvency models for predicting ...
Excipients Examples Effect on Complexation Enhancement Some Brief Observations Acids, bases, inorganic/organic salts hydrochloride, citrate, aspartate, mesylate, maleate, tartrate, phosphate, acetate Increase intrinsic solubility of drugs (S0) and/or the apparent stability constant (K1:1)...
The influence of dendrimer solution pH on the solubility enhancement of ibuprofen suggests that it involves an electrostatic interaction between the carboxyl group of the ibuprofen molecule and the amine groups of the dendrimer molecule.Milhem, O. M....
solubility enhancementMelt granulationsolid dispersionalkalizerPEG 6000Background and Objective: The present work discusses the use of alkalizer based solid dispersion approach for solubility enhancement of Ibuprofen (IBP). Ibuprofen, a BCS Class II drug shows dissolution rate limited absorption and pH ...
The objective of the present investigation was to prepare physical mixtures to investigate the enhancement of the aqueous solubility and dissolution of ibuprofen(a poorly soluble, weakly acidic, NSAID) using some selected hydrophilic carriers with the different ratio. The prepared ibuprofen physical ...
When evaluating the food- or formulation-induced enhancement of compound concentrations in complex gastrointestinal fluids, it is important to distinguish between (i) supersaturation, which temporarily increases the concentration of freely dissolved molecules above the molecular equilibrium solubility, and (ii...
A great attention has been paid on cyclodextrin-based nanosponge (CDNS) as a cross-linked, porous and solid polymeric drug delivery system with spherical morphology and high ability to increase drug loading capacity and achieve a prolonged drug release with enhancement of bioavailability, solubility ...