RACEMIC COMPOUNDPHASE DIAGRAMSOLUBILITYA binary phase diagram constructed from DSC curves of ibuprofen (IB) using R-IB, S-IB and ibuprofen USP (rac-IB) was typical of a eutectic system with addition compound formation. The USP material is therefore a racemic compound which melts at 71掳C ...
When the solubility values of acetaminophen and racemic (±)-ibuprofen at 25 °C were plotted against the dielectric constant of various solvents (see Table I) in which the APIs were soluble, the APIs' characteristic "solubility pattern" was produced (see Figures 4 and 5...
At the moment I have a project regarding: Differences in solubility of diasteromeric salts and isolating one enantiomer from a racemic mixture. We are working with (RS)-2(4'-isobutylphenyl)propionic acid (ibuprofen)However, there is a question I have really hard time figuring out and it ...
wherein the terms “R” and “S” are as defined in Pure Appl. Chem. (1976) 45, 13-10. Compounds having asymmetrically substituted carbon atoms with equal amounts of R and S configurations are racemic at those atoms. Atoms having excess of one configuration over the ...
Compounds having asymmetrically substituted carbon atoms with equal amounts of R and S configurations are racemic at those atoms. Atoms having excess of one configuration over the other are assigned the configuration in excess, preferably an excess of about 85%-90%, more preferably an excess of ...
The article examines the use of racemic compound (R,S)-(卤)-ibuprofen, which is a known active pharmaceutical ingredient. Researchers found that the racemic compound has a number of disadvantageous formulation properties such as poor solubility, low melting point and potential esterification with ...
Solubility, polymorphism, crystallinity, and crystal habit of acetaminophen and racemic (±)-ibuprofen were determined by initial screening of 23 solvents for scale-up. Solubility curves were constructed, and solubility at 25 °C was plotted against the dielectric constants of various solvent as a ...