别名 [14C]-Sodium Valproate、Depakote ER、Divalproex + [13] 靶点 GABA receptor x Sodium channels 作用机制 GABA receptor激动剂(γ-氨基丁酸受体激动剂)、钠通道阻滞剂 治疗领域 神经系统疾病其他疾病 在研适应症 躁郁症偏头痛癫痫的复杂部分性发作+ [2] 非在研适应症 酒精相关疾病酗酒躁郁症1型+ [3] ...
A 60 year old patient with bipolar affective disorder presented with clinical features suggestive of encephalopathy two weeks after commencing treatment with sodium valproate. He developed sudden onset alteration of sleep pattern, extreme agitation and hallucinations. He was disoriented in time, place, ...
Sodium valproate was changed to lamotrigine with both a rapid improvement of tremor and an optimal control of symptoms.In conclusion we documented that sodium valproate is able to induce in a patient with epilepsy and Downs syndrome, the development of tremor probably through the decreased activity ...
The rate of clinical response of oral loading sodium valproate in acutely manic patient. J Res Med Sci 2003; 8: 25-29.Shafiee, K., M. Barekateyn, N. Bashardoost and J. Mahmoudi Ghariee, 2003. The Rate of Clinical Response of Oral Loading SODIUM VALPROATE in Acutely MANLC Patient. ...
A Medication Guide describing the risks of valproate is available for patients [seePATIENT INFORMATION]. Pancreatitis Cases of life-threateningpancreatitishave been reported in both children and adults receiving valproate. Some of the cases have been described ashemorrhagicwith a rapid progression from in...
Applies to: Valproate Sodium (valproic acid) Alcohol can increase the nervous system side effects of valproic acid such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while bei...
AMedication Guidedescribing the risks of valproate is available for patients [seePATIENT INFORMATION]. Pancreatitis Cases of life-threatening pancreatitis have been reported in both children and adults receiving valproate. Some of the cases have been described as hemorrhagic with a rapid progression from...
Phenobarbital and valproate may increase or decrease serum phenytoin concentrations; effect of phenytoin on phenobarbital and valproate concentrations is unpredictable Monitor serum phenytoin concentrations and adjust dosage of phenytoin accordingly Dosage adjustment of some anticonvulsants may be necessary when ...
DOI: 10.2478/s11536-007-0007-5CasereportCEJMed 2(1) 2007 103–107Paradoxical effect of sodium valproate thataggravates epilepsy of MELAS in a patient withA3243G mutation of the mitochondrial DNAYi-Min Chen1, Chih-Ming Lin1, Peterus Thajeb1,2,3∗1Departments of Neurology and Medical Resea...
In 4 cases a marked improvement was observed after valproate medication whereas one patient showed no response. Seven further patients with frequently recurrent episodes of a manic or maniform schizoaffective psychosis, irresponsive to lithium prophylaxis, were chronically treated with valproate in ...