Antiepileptic drugs Phenobarbital, valproate sodium‡, valproic acid$ *Antacids may affect absorption of phenytoin. †The induction potency of St. John’s wort may vary widely based on preparation. ‡Valproate sodium and valproic acid are similar medications. The term valproate has been used to...
Administration of a single oral 50 mg dose ofamitriptylineto 15 normal volunteers (10 males and 5 females) who received valproate (500 mg BID) resulted in a 21% decrease in plasma clearance of amitriptyline and a 34% decrease in the net clearance of nortriptyline. Rare postmarketing reports o...
Administration of a single oral 50 mg dose ofamitriptylineto 15 normal volunteers (10 males and 5 females) who received valproate (500 mg BID) resulted in a 21% decrease in plasma clearance of amitriptyline and a 34% decrease in the net clearance of nortriptyline. Rare postmarketing reports o...