The article presents a study which investigates the effects of sodium valproate on the brain volume of epileptic patients and found significant reduction parietal lobe thickness in 36 male patients with focal intractable epilepsy.doi:10.1007/s40278-013-3074-1Reactions Weekly...
别名 [14C]-Sodium Valproate、Depakote ER、Divalproex + [13] 靶点 GABA receptor x Sodium channels 作用机制 GABA receptor激动剂(γ-氨基丁酸受体激动剂)、钠通道阻滞剂 治疗领域 神经系统疾病其他疾病 在研适应症 躁郁症偏头痛癫痫的复杂部分性发作+ [2] 非在研适应症 酒精相关疾病酗酒躁郁症1型+ [3] ...
摘要: Three patients with organic and affective symptoms related to multiple sclerosis or systemic lupus erythematosus responded dramatically to sodium valproate after other treatments had failed.DOI: 10.1176/ajp.145.8.1010 被引量: 67 年份: 1988 ...
The Impact of Sodium Valproate and Phenytoin on Cognitive Function in Elderly Patients: Results of a Single-Blind Comparative Study.CraigThe University of Manchester Department of Geriatric MedicineI.R.The University of Manchester Department of Geriatric MedicineTallis...
, Calzetti S. , Visintini D. Disposition of sodium valproate in epileptic patients . Br J Clin Pharmacol 1978b ; 5 : 495 – 9 .Perucca E, Gatti G, Frigo GM, et al. Disposition of sodium valproate in epileptic patients. Br J Clin Pharmacol 1978b; 5: 495–9...
Prolonged use of sodium valproate can affect liver function, so patients taking the medication are often monitored for any signs of liver damage. It is also associated with an increased risk of birth defects when used during pregnancy, and as such, is classified as a Category D drug by the ...
Electroencephalographic and behavioural effects of sodium valproate in patients with photosensitive epilepsy. A single dose trial. Petit malVisual evoked potentialsPhotoconvulsive responseA single oral dose of Sodium valproate (VPA) given as Epilim (10 mg/kg) inhibited photoconvulsive ... MS Myslobod...
Objective To investigate the clinical efficacy and safety of Sodium Valproate Sustained Release Tablets(depakine) in treatment of the patients with manic episode of Bipolar disorder type 1. Methods In the 4-week randomly controlled trial,40 patients were treated with depakine and 40 patients with Lit...
A Medication Guide describing the risks of valproate is available for patients [seePATIENT INFORMATION]. Pancreatitis Cases of life-threateningpancreatitishave been reported in both children and adults receiving valproate. Some of the cases have been described ashemorrhagicwith a rapid progression from in...
AMedication Guidedescribing the risks of valproate is available for patients [seePATIENT INFORMATION]. Pancreatitis Cases of life-threatening pancreatitis have been reported in both children and adults receiving valproate. Some of the cases have been described as hemorrhagic with a rapid progression from...