HCO3 transporters arising from the SLC4a gene family are involved in maintenance of intracellular pH and transepithelial HCO3 movement in many rodent tissues. However, little is known about the importance of such proteins in humans or even whether the expression pattern is similar to rodents. This ...
Ecelbarger CA, Tiwari S (2006) Sodium transporters in the distal nephron and disease implications. Curr Hypertens Rep 8:158–165 PubMedCAS Entingh-Pearsall A, Kahn CR (2004) Differential roles of the insulin and insulin-like growth factor-I (IGF-I) receptors in response to insulin and IGF...
There are two classes of glucose transporters involved in glucose homeostasis in the body, the facilitated transporters or uniporters (GLUTs) and the active transporters or symporters (SGLTs). The energy for active glucose transport is provided by the sodium gradient across the cell membrane, the...
We found high gene expression ofSLC23A1but no expression ofSLC23A2in the proximal convoluted and straight tubules of humans. These data rule outSLC23A2as the ascorbic acid release protein in the renal proximal tubular epithelia cell. We utilized a novel dual transporter-basedXenopus laevisoocyte ...
Sodium glucose transporters (SGLTs) belong to the mammalian solute carrier family SLC5. This family includes 12 different members in human that mediate the transport of sugars, vitamins, amino acids, or smaller organic ions such as choline. The SLC5 family belongs to the sodium symporter family...
in the apical membrane of proximal tubuli: type I (NaPi-I or Npt1), although these are believed to transport mainlyorganic phosphateand multiple other anions as well, type II (NaPi-IIa and NaPi-IIc) and type III (PiT2) transporters (Tatsumi et al., 2016). Patients with a homozy...
Among the type I phosphate transporters, only NPT1 and NPT4 have high expression in kidney. B, the diagrams of two isoforms of SLC17A3 (NPT4). Two isoforms of NPT4 differ in one exon (lacking the fourth exon for short isoform; isoform 2), the long isoform consists of 13 exons, and...
The SLC13 family in humans and other mammals consists of sodium-coupled transporters for anionic substrates: three transporters for dicarboxylates/citrate and two transporters for sulfate. This review will focus on the di- and tricarboxylate transporters: NaDC1 (SLC13A2), NaDC3 (SLC13A3), and ...
jejuni- infected humans revealed that the acute inflammatory response is a hallmark of the C. jejuni infection,6,7 in which mucosal invasion is a main virulence characteristic of C. jejuni.8 C. jejuni when invaded into the subepithelium can induce inflammation leading to leukocyte infiltration of...
As indicated by their name, SGLTs form a family of carriers, which are responsible for translocating glucose and Na+across theapical membraneby utilizing the downhill Na+gradient provided by the activity of the Na+/K+-ATPase. Out of six SGLT isoforms discovered in humans (se...