Over the last two decades, the understanding of how dysregulated ion channels and transporters are involved in carcinogenesis and tumor growth and progression, including invasiveness and metastasis, has been increasing exponentially. The present review s
Sodium ions enter the cell through the open sodium channels. The positive charge that they carry makes the inside of the cell slightly less negative (depolarizes the cell). When the depolarization reaches a certain threshold value, many more sodium channels in that area open. More sodium flows...
Sodium ion channel mutations in glioblastoma patients correlate with shorter survival Mol. Cancer, 10 (2011), p. 17, 10.1186/1476-4598-10-17 View in ScopusGoogle Scholar [6] K. Stegmaier, K.N. Ross, S.A. Colavito, S. O’Malley, B.R. Stockwell, T.R. Golub Gene expression-based hi...
However, InsP3-dependent source of astroglial Ca2+ may not be at play in the regulation of synaptic transmission and plasticity. Sodium signaling and energy metabolism In addition, despite overwhelming evidence pointing toward the key function of Ca2+ elevation in astrocytes, one...
(Milne and Beamish1999; De Luccia2012). This finding is interesting, because plants do not have specific animal-type sodium channels (Hedrich2012), indicating also some general target of local anaesthetic. To reveal the possible mechanism responsible for the complete immobilization of leaves, Yokawa...
How LeuT shapes our understanding of the mechanisms of sodium-coupled neurotransmitter transporters . J Physiol 2014; 592 : 863–869. doi: 10.1113/jphysiol.2013.259051Penmatsa A, Gouaux E. How LeuT shapes our understanding of the mechanisms of sodium-coupled neurotransmitter transporters. J Physiol....
Crystals were cryo-protected with a solution composed of equal volumes of mother liquor and 3.4 M sodium malonate at pH 7.0 and subsequently flash-cooled in liquid nitrogen. Structure determination and refinement Synchrotron diffraction data were collected at the beamline 14.1 and 14.2 of the MX...
Interestingly, a recent study demonstrated that the sodium–calcium exchanger, which is also regulated by PIP2, displays similar regulation by LC-CoA (Riedel et al., 2006). It will therefore be interesting to see whether other PIP2-regulated channels or transporters also ex- ...
In addition, these approaches will be useful for under- standing zinc physiology from studies of over-expressing or knocking out zinc transporters, time and dose dependent zinc stimulation, or studying specific diseases linked to aber- rant zinc homeostasis. Combining such data with molecu- lar ...
Flowers TJ, Munns R, Colmer TD (2015) Sodium chloride toxicity and the cellular basis of salt tolerance in halophytes. Ann Bot 115:419–431 CASPubMedGoogle Scholar Frukh A, Siddiqi TO, Khan MIR, Ahmad A (2020) Modulation in growth, biochemical attributes and proteome profile of rice cult...