The most used of oral anti-diabetic agents is metformin that activates glucose transport vesicles to the cell surface. Others are: the sulphonylureas; agents acting on the incretin system; GLP-1 agonists; dipetidylpeptidase-4 inhibitors; meglinitide analogues; and the thiazolidinediones. Despite ...
Thus, sodium glucose cotransporter 2 inhibitors (SGLT2i) target the kidney by blunting glucose transport, promoting urinary glucose excretion and a decrease of hyperglycemia [94•,95]. Due to their insulin-independent mechanism of action, SGLT2i are generally well tolerated, asso...
The SGLT2 localization in the S1 segment of the early proximal tubule and its high capacity for glucose transport fit well with its major role in renal glucose reabsorption. From: Annual Reports in Medicinal Chemistry, 2011 Related terms: Canagliflozin Insulin Dapagliflozin Glucose Sodi...
20 ± 2 26 ± 2*,w 475 ± 6* 539 ± 18* 112 ± 5 109 ± 5 6.0 ± 0.1 89 ± 6 122 ± 20* 0.30 ± 0.01 108 ± 13* combined with the Newman–Keuls post hoc test. P-values of o0.05 were considered as statistically significant. RESULTS Metabolic parameters and urinary glucose ...
SGLT2 activation through KATPchannels by dapagliflozin [4]. Glucagon secretion and hepatic gluconeogenesis were improved in normal mice treated with dapagliflozin, and fasting-induced hypoglycemia was limited [4,29]. The effect of SGLT1 on glucagon secretion depends on glucose transport, not glucose ...
Musso G,Gambino R,Cassader M,et al.A novel approach to control hyperglycemia in type 2 diabetes:sodium glucose co-transport(SGLT) inhibitors:systematic review and meta-analysis of randomized trials[J].Ann Med,2012,44(4):375-393.DOI: 10.3109/07853890.2011.560181. [37] Blonde L,Stenlöf...
This cohort study examines the use of sodium/glucose cotransporter 2 inhibitor therapy in patients with type 2 diabetes at risk for gout.
Intestinal sugar transport in ruminants. the sodium-dependent D-glucose cotransporter (SGLT1) and facilitated glucose transporter (GLUT 2) at the brush border and basolateral membranes, respectively... SP Shirazi-Beechey,D Scott,J Dyer,... - 《Proceedings of the Society of Nutrition Physiology》 ...
(SGLT) are a family of glucose transporter chiefly exist in the intestinal mucosa of the small intestine (SGLT1) and theproximal tubule of the nephron (SGLT1 and SGLT2), the membrane protein SGLT expressed are responsible for the transport of glucose, amino acids, vitamins, ions and ...
Sodium glucose transport 2 (SGLT2) inhibition decreases glomerular hyperfiltration: is there a role for SGLT2 inhibitors in diabetic kidney disease? Circulation, 129 (2014), pp. 542-544 View in ScopusGoogle Scholar 65 R. Santer, J. Calado Familial renal glucosuria and SGLT2: from a Mendelian...