Sodium–glucose cotransporter protein 2 (SGLT-2) inhibitors, novel hypoglycemic agents, have been shown to reduce body weight and blood pressure and may serve as potential novel agents for the treatment of obesity-associated hypertension. This review discusses the beneficial mechanisms of ...
Sodium glucose cotransporter 2 is a glucose transport protein expressed in the proximal renal tubule that regulates the reabsorption of glucose and is increased in patients with T2D. Thus, sodium glucose cotransporter 2 inhibitors (SGLT2i) target the kidney by blunting glucose transp...
(SGLT-2) inhibitor,a new type of hypoglycemic agent,may effectively lower blood glucose,improve renal hyperfiltration,lower blood pressure,reduce urinary protein,improve renal hypoxia,reduce inflammation and oxidative stress,lower serum uric acid,weight and plasma lipids,etc.This review summarized its ...
± 2 23 ± 2* 480 ± 12* 572 ± 21* 104 ± 6 108 ± 6 6.1 ± 0.2 102 ± 13* 124 ± 36* 0.32 ± 0.01 140 ± 25* Abbreviations: Cr, creatinine; LETO rats, Long Evans Tokushima Otsuka rats; OLETF rats, Otsuka Long Evans Tokushima Fatty rats; PPBG, postprandial blood glucose....
The SGLT2 localization in the S1 segment of the early proximal tubule and its high capacity for glucose transport fit well with its major role in renal glucose reabsorption. From: Annual Reports in Medicinal Chemistry, 2011 Related terms: Canagliflozin Insulin Dapagliflozin Glucose Sodi...
3)Glucose transport protein葡萄糖转运蛋白 1.Three kinds of cells were treated with emodin and rhein, and the PPARγ and glucose transport protein ( GLUT ) proteins expression levels were evaluated by Western blot analysis.将大黄素和大黄酸与诱导成熟的可用于实验的细胞进行培养,Western杂交法测定PPARγ...
SGLT2 activation through KATPchannels by dapagliflozin [4]. Glucagon secretion and hepatic gluconeogenesis were improved in normal mice treated with dapagliflozin, and fasting-induced hypoglycemia was limited [4,29]. The effect of SGLT1 on glucagon secretion depends on glucose transport, not glucose ...
Sodium-glucose cotransporter-2 inhibitors (SGLT2i) are now recommended for patients with heart failure, but the mechanisms that underlie the protective role of SGLT2i in cardiac remodeling remain unclear. Aldehyde dehydrogenase 2 (ALDH2) effectively prevents cardiac remodeling. Here, the key role of...
6. Rationale for SGLT-2 therapeutics in COVID-19 6.1. Pharmacology of SGLT-2 inhibitors SGLT-1 and SGLT-2 are sodium glucose co-transporter proteins which play an important role in glucose homeostasis. SGLT-2 is the major transport protein that mediates approximately 90% glucose reabsorption fro...
(SGLT) are a family of glucose transporter chiefly exist in the intestinal mucosa of the small intestine (SGLT1) and theproximal tubule of the nephron (SGLT1 and SGLT2), the membrane protein SGLT expressed are responsible for the transport of glucose, amino acids, vitamins, ions and ...