Sodium glucose cotransporter 2 inhibitors EMPA-REG OUTCOME [114•] n = 7020 T2D and CVD MACEa Empagliflozin versus placebo 0.86 (0.74–0.99) P < 0.001 non-inferiority, P = 0.04 superiority Genital infections, bone fractures. CANVAS and CANVAS-R [118] n = 4330 T2D/at...
Sodium–glucose cotransporter2 inhibitors represent a paradigm shift in the prevention of heart failure in type2 diabetes patientsHeart failureSodium–glucose cotransporter2 inhibitorType2 diabetes mellitusRecent major clinical trials of the use of sodium銈瀕ucose cotransporter 2 (SGLT2) inhibitors in ...
葡萄糖注射液 葡萄糖注射液 拼音名:Putaotang Zhusheye 英文名:Glucose Injection 书页号:2000年版二部-816 本品为葡萄糖或无水葡萄糖的灭菌水溶液。含葡萄糖(C6H12O6.H2O) 应为标示量的 95.0%～105.0%。 【性状】 本品为无色或几乎无色的澄明液体;味甜。 【鉴别】 取本品,缓缓滴入温热的碱性酒石酸铜...
Sodium-glucose cotransporter-2 inhibitors (SGLT2i) are a new class of oral anti-hyperglycemic agents. Physiologically, glucose filtered through kidney glomeruli is reabsorbed in the proximal convoluted tubule; SGLT2i inhibit this mechanism. Therefore, glucose is secreted in the urine (glucosuria) ...
Sodium鈥揼lucose cotransporter 2 inhibitors (SGLT2i), a new drug class initially designed and approved for treatment of diabetes mellitus, have been shown to exert pleiotropic metabolic and direct cardioprotective and nephroprotective effects that extend beyond their glucose-lowering action. These ...
Sodium–glucose cotransporter 2 inhibitors and skeletal muscle In this issue is a small report concerning muscle biopsies taken from patients with heart failure and reduced ejection fraction (HFrEF) who were, or were not, taking a sodium鈥揼lucose cotransporter 2 (SGLT2) inhibitor.1 The unique ...
Sodium-glucose cotransporter (SGLT) 2 inhibitors were recently approved as glucose-lowering interventions in people with type 2 diabetes mellitus (T2DM). Potential beneficial or harmful effects of SGLT 2 inhibitors in people at risk for the development of T2DM are unknown. To assess the effects of...
Greco, A. Sodium-Glucose Cotransporter-2 Inhibitors: Elevating Standards in Cardiovascular Secondary Prevention. Am J Cardiovasc Drugs 24, 625–628 (2024). https://doi.org/10.1007/s40256-024-00666-0 Download citation Accepted03 July 2024 Published17 July 2024 Issue DateSeptember 2024 DOIhttps://...
2. Sodium-Glucose Cotransporters SGLT-1/SGLT-2: Attractive Molecular Targets for Drug Development 3. SGLT-1 and SGLT-2 Inhibitors: From Discovery to Development as Novel Therapeutic Agents 4. Conclusions and Perspectives conflict-of-interest References VitaeShow full outline Cited by (24) Figures...
The aim of this study was to examine if the sodium-glucose cotransporter (SGLT2) inhibition prevents the oxidative stress in the kidney of diabetic rats. Methods. The diabetic rat model was established by intraperitoneal injection of streptozotocin (50???mg/kg). The inhibition of SGLT2 was ...