SGLT-2抑制剂,中文名为钠-葡萄糖协同转运蛋白2(sodium-dependent glucose transporters 2,SGLT-2)抑制剂,可以抑制肾脏对葡萄糖的重吸收,使过量的葡萄糖从尿液中排出,降低血糖。这是一类新型抗糖 - 控糖专家沈创鹏于20230823发布在抖音,已经收获了58.6万个喜欢,来抖音
Abstract 14007: Sodium-Dependent Glucose Transporters 2 Inhibition Ameliorates Obesity-Induced Metabolic Changes and CardiomyopathyCardiomyopathyObesityIntroduction:\nInhibition of renal sodium-glucose cotransporter-2 (SGLT2) reduces urinary glucose reabsorption to decrease glycemia. Recent large-scale trials have...
SGLT2 inhibitors are a newer class of glucose-lowering drugs that reduce serum glucose by inhibiting its tubular reabsorption in the kidney and thereby inducing urinary glucose excretion (Yaribeygi et al., 2019, Davidson and Kuritzky, 2014). ...
Within the family of sodium-dependent glucose transporters, sodium-glucose co-transporter-1 (SGLT-1) and SGLT-2 transporters are key regulators of glucose reabsorption filtered by the kidney, with expression on 2 regions of the renal proximal convoluted tubule.The majority...
Sodium-dependent glucose co-transporters (or sodium-glucose linked transporters, SGLT2) are a family of glucose transporter. It is exclusively expressed in the proximal renal tubules, accounting for about 90% of the reabsorption of glucose from tubular fluid [71]. In March 2013, ca...
We also observed that SGLT2 immunostaining was faint in empagliflozin-treated rats, suggesting 1.5 1.5 11 0.5 0.5 0 LETO OLETF OLETF +empagliflozin 0 LETO OLETF OLETF +empagliflozin LETO OLETF OLETF + empagliflozin Figure 6 Gene expression of sodium-dependent glucose co-transporter 2 (SGLT2, a)...
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Methods The expression of glucose transporters in SMMC-7721 cell was detected by RT-PCR. 方法利用RT-PCR检测SMMC-7721(以下简称7721)细胞中葡萄糖转运蛋白(GLUT)的表达情况,利用Western blot、免疫沉淀及凝集素印迹分析检测转染了反义GnT-V的SMMC-7721细胞(以下简称As/7721)以及转染空质粒pcDNA3的SMMC-7721细...
Synthetic approaches and clinical application of small-molecule inhibitors of sodium-dependent glucose transporters 2 for the treatment of type 2 diabetes mellitus 2024, European Journal of Medicinal Chemistry Citation Excerpt : Furthermore, compared to Dapagliflozin, the HbA1c change of Enavogliflozin-...
Sodium-dependent glucose transporters (SGLT) in human ischemic heart: a new potential pharmacological target Int J Cardiol, 243 (2017), pp. 86-90 View PDFView articleView in ScopusGoogle Scholar [42] A. Baartscheer, C.A. Schumacher, R.C. Wust, J.W. Fiolet, G.J. Stienen, R. Coronel...