compartments.The NCKX(SLC24) branch of Na~+/Ca~(2+)-exchangers transport K~+ and Ca~(2+) in exchange for Na~+,and comprises five members.The NCKX proteins probably play a particularly prominent role in regulating Ca~(2+) flux in environments which experience wide and frequent ...
Sodium cations are important in neuron (brain and nerve) function, and in influencing osmotic balance between cells and the interstitial fluid, with their distribution mediated in all animals (but not in all plants) by the so-called Na+/K+-ATPase pump.[20] Sodium is the chief cation in fl...
Besides, abnormal renal unit function, such as ischemia of the nephron that produces renin, or a decrease in the number of nephrons with age, will weaken the kidneys' ability to excrete sodium. In addition, the decrease in filtration area caused by glomerulosclerosis and other factors will also...
Amsel A . Hippocampal function in the rat: cognitive mapping or vicarious trial and error? Hippocampus 1993;3:251–6. Article CAS Google Scholar Chen W, Ma Q, Suzuki H, Hartman R, Tang J, Zhang JH . Osteopontin reduced hypoxia-ischemia neonatal brain injury by suppression of apoptosis in...
In this study, the latest research findings regarding the structure, type, distribution, and function of VGSCs in the nervous system and their relationship to neurological diseases, such as epilepsy, neuropathic pain, brain tumors, neural trauma, and multiple sclerosis, are reviewed in detail....
Cardiac arrest (CA) is one of the most common illnesses worldwide. Post-CA brain injury (PCABI) is a major cause of death and poor recovery in CA patients and the current CA treatments are not very effective. The microbiome-gut-brain axis has been found
Genetic and phenotypic heterogeneity suggest therapeutic implications in SCN2A-related disorders. Brain 140, 1316–1336 (2017). This article describes the correlation of age of seizure onset with degree of impairment of Nav1.2 channel function. PubMed Google Scholar Ogiwara, I. et al. De novo ...
The swollen neurons compensate by losing electrolytes and other substances so that within a few days, the brain returns to its normal size. It is these adaptive changes that make the brain susceptible to damage during too‐rapid correction of the hyponatremia. Rapid correction of hyponatremia can ...
Excitable cells — including neurons, muscle cells and cardiac myocytes — are unique in expressing high densities of voltage-gated sodium (NaV) channels. This molecular adaptation enables these cells to produce action potentials, and is essential to the
A few brain regions are exempted from this tight enclosure. Notably, the capillary endothelium adjacent to the vascular organ of the lamina terminalis in the hypothalamus allows the relatively free exchange of sodium. Osmoreceptors in this area sense blood osmolality and thus sodium concentration (...