Ke X, Taylor MS, Cardon LR. Singleton SNPs in the human genome and implications for genome-wide association studies. Eur J Hum Genet. 2008;16(4):506–15.Ke X, Taylor MS, Cardon LR (2008) Singleton SNPs in the human genome and implications for genome-wide association studies. Eur J ...
Approximately how many genes does the human genome include? How many autosomal chromosomes does a human have? How many autosomal cells do humans have? How many genes are in the human body? What percent of human genome point mutations are deleterious?
However, it is well established that half of all MIs occur in individuals without overt hyperlipidemia. The Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group effectsare low, the most serious side effect, myositis with rhabdomyolysis, is life threatening doi...
Most of the millions of SNPs in the human genome are non-coding, and many overlap with putative regulatory elements. Genome-wide association studies (GWAS) have linked many of these SNPs to human traits or to gene expression levels, but rarely with sufficient resolution to identify the causal ...
A periodic pattern of SNPs in the human genome. By surveying a filtered, high-quality set of SNPs in the human genome, we have found that SNPs positioned 1, 2, 4, 6, or 8 bp apart are more frequent than ... Madsen,E Bo,Villesen,... - 《Genome Research》 被引量: 16发表: ...
The number of reads supporting the wild type and alternate allele at 6059 SNPs in the human genome are counted and a Bayesian approach is used to calculate a p-value for the null hypothesis that the two samples are derived from the same individual. W = Wild Type; A = Alternate Allele ...
human genome. SNPs result from single base differences between genome sequences, and are as the crucial factor of susceptibility and drug reaction. In this review, we focused on the features and sorts of SNPs, introduced the progress on SNPs in human genome, and the application of SNPs in ...
detecting specific single nucleotide polymorphisms (SNPs) in the genome of human fetus, and their association with acute coronary events and/or variability in the responsiveness to statin treatment (including preventive treatment) between different individuals; assessing for risk of heart disease...
HumanGenomeProject—n.人类基因组计划 SNPs 99.9%ofoneindividualDNAsequenceswillbeidenticaltothatofanotherperson.Ofthe0.1%difference,over80%willbesinglenucleotidepolymorphisms(SNPs).ASNPisasinglebasesubstitutionofonenucleotidewithanother,andbothversionsareobservedinthegeneralpopulationatafrequencygreaterthan1%.Definiti...
- 《Human Molecular Genetics》 被引量: 849发表: 2007年 Hippocampal Atrophy as a Quantitative Trait in a Genome-Wide Association Study Identifying Novel Susceptibility Genes for Alzheimer's Disease BackgroundWith the exception of APOE 蔚4 allele, the common genetic risk factors for sporadic Alzheimer...