Detection of regulatory SNPs in human genome using ChIP-seq ENCODE data. PLoS One. 2013;8(10):e78833.Bryzgalov LO, Antontseva EV, Matveeva MY, Shilov AG, Kashina EV, Mordvinov VA, et al. Detection of regulatory SNPs in human genome using ChIP-seq ENCODE data. PLoS One. 2013; 8 :...
However, it is well established that half of all MIs occur in individuals without overt hyperlipidemia. The Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group effectsare low, the most serious side effect, myositis with rhabdomyolysis, is life threatening doi...
A plethora of SNPs has been distributed in human genome. Due to their association with different diseases, these variations can preferentially act as genetic markers [36]. Studying such a large number of SNPs in case-control association studies offers a great challenge for scientists. Computational...
human genome. SNPs result from single base differences between genome sequences, and are as the crucial factor of susceptibility and drug reaction. In this review, we focused on the features and sorts of SNPs, introduced the progress on SNPs in human genome, and the application of SNPs in ...
detecting specific single nucleotide polymorphisms (SNPs) in the genome of human fetus, and their association with acute coronary events and/or variability in the responsiveness to statin treatment (including preventive treatment) between different individuals; assessing for risk of heart disease...
(-STAT) signaling pathway, which is activated by a plethora of cytokines and crucial in controlling immune responses and has been implicated in diseases like cancer, autoimmune disorders, and responses to viral infections. The protocol involves scanning the entire human genome (hg38) to pinpoint ...
The article discusses a study which provides the first genome-wide investigation of the relationship between common human genetic variation and levels of disease-related proteins. Researchers looked for associations between common single nucleotide polymorphisms and the blood levels of proteins for which ...
(TFs) that bind to DNA by recognizing specific sequences. The human genome is estimated to contain more than 1,600 human TFs, comprising more than 70 DNA-binding domain types [1]. Studies on TF-binding sites have revealed that TFs do not bind to a single sequence, but rather to a ...
the human NLI-IF gene: evidence of human origin and lack of association with tuberculosis susceptibility Received: December 13, 2001 / Accepted: January 8, 2002 Abstract Sequence variation in the human genome has been used as a tool in studying human diseases and the evolutionary history of man...
(T) nucleotide within a particular DNA fragment. SNPs are pervasive in human DNA, occurring roughly once every 1,000 nucleotides on average, resulting in approximately 4 to 5 million SNPs within an individual's genome. To be classified as SNPs, these variations must be present in at least ...